Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the
native regenerative properties of skeletal muscle and results in lifelong functional deficits …

Our goal was to understand the impact of regenerative therapies on the functional capacity
of skeletal muscle following volumetric muscle loss (VML) injury. An extensive database …

Volumetric muscle loss (VML) is an irrecoverable injury associated with muscle loss greater
than 20%. Although hydrogel-based 3D engineered muscles and the decellularized …

Volumetric muscle loss (VML) is associated with loss of skeletal muscle function, and current
treatments show limited efficacy. Here we show that bioconstructs suffused with genetically …

Extremity injuries comprise the majority of battlefield injuries and contribute the most to long-
term disability of servicemembers. The purpose of this study was to better define the …

Volumetric muscle loss (VML) is a severe and debilitating clinical problem. Current standard
of care includes physical therapy or orthotics, which do not correct underlying strength …

Extracellular matrix (ECM) derived scaffolds continue to be investigated for the treatment of
volumetric muscle loss (VML) injuries. Clinically, ECM scaffolds have been used for lower …

Volumetric muscle loss (VML) resulting from extremity trauma presents chronic and
persistent functional deficits which ultimately manifest disability. Acellular biological …

Adult skeletal muscle can regenerate effectively after mild physical or chemical insult.
Muscle trauma or disease can overwhelm this innate capacity for regeneration and result in …

Acellular bioscaffolds composed of extracellular matrix (ECM) have been effectively used to
promote functional tissue remodeling in both preclinical and clinical studies of volumetric …