Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …

Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …

Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they …

The process of cardiac morphogenesis in humans is incompletely understood. Its full
characterization requires a deep exploration of the organ-wide orchestration of gene …

Owing to the prevalence and high mortality rates of cardiac diseases, a more detailed
characterization of the human heart is necessary; however, this has been largely impeded …

The heart is the central organ of the circulatory system, and its proper development is vital
for maintaining human life. Here, we used single-cell RNA sequencing to profile the gene …

Single-cell RNA sequencing is a powerful tool to study developmental biology but does not
preserve spatial information about tissue morphology and cellular interactions. Here, we …

INTRODUCTION The vertebrate heart is composed of diverse cell types, all essential for
normal cardiac function. In the mouse, the earliest mesodermal progenitors of …

Organogenesis involves integration of diverse cell types; dysregulation of cell-type-specific
gene networks results in birth defects, which affect 5% of live births. Congenital heart defects …

The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …