Cyclooxygenase in biology and disease
RN Dubois, SB Abramson, L Crofford… - The FASEB …, 1998 - Wiley Online Library
Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to
prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit …
prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit …
Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action
SS Ayoub - Temperature, 2021 - Taylor & Francis
Paracetamol (acetaminophen) is undoubtedly one of the most widely used drugs worldwide.
As an over-the-counter medication, paracetamol is the standard and first-line treatment for …
As an over-the-counter medication, paracetamol is the standard and first-line treatment for …
Cyclooxygenase-2: a therapeutic target
ME Turini, RN DuBois - Annual review of medicine, 2002 - annualreviews.org
▪ Abstract Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is
the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX …
the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX …
Hypothermic and antipyretic effects of 3-methyl-and 3-phenyl-5-hydroxy-5-trichloromethyl-4, 5-dihydro-1H-pyrazole-1-carboxyamides in mice
FR Souza, VT Souza, V Ratzlaff, LP Borges… - European journal of …, 2002 - Elsevier
The effect of novel pyrazolines, 3-methyl-5-hydroxy-5-trichloromethyl-4, 5-dihydro-1H-
pyrazole-1-carboxyamide (MPCA) and 3-phenyl-5-hydroxy-5-trichloromethyl-4, 5-dihydro …
pyrazole-1-carboxyamide (MPCA) and 3-phenyl-5-hydroxy-5-trichloromethyl-4, 5-dihydro …
Randomized pilot study of nimesulide treatment in Alzheimer's disease
PS Aisen, J Schmeidler, GM Pasinetti - Neurology, 2002 - AAN Enterprises
Background: Nonsteroidal anti-inflammatory drugs (NSAID) may be useful in the treatment of
AD. Clinical and laboratory experience with nimesulide, an NSAID with preferential …
AD. Clinical and laboratory experience with nimesulide, an NSAID with preferential …
Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease
PE Lipsky, P Brooks, LJ Crofford… - Archives of Internal …, 2000 - jamanetwork.com
Originally suggested to function mainly in inflammatory situations, recent data have implied
important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes …
important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes …
Modulation of nuclear factor-κB activity by indomethacin influences Aβ levels but not Aβ precursor protein metabolism in a model of Alzheimer's disease
S Sung, H Yang, K Uryu, EB Lee, L Zhao… - The American journal of …, 2004 - Elsevier
Epidemiological studies show that some nonsteroidal anti-inflammatory drugs, nonspecific
inhibitors of the cyclooxygenase enzyme, reduce the incidence of Alzheimer's disease (AD) …
inhibitors of the cyclooxygenase enzyme, reduce the incidence of Alzheimer's disease (AD) …
Influences of solution chemistry and polymeric natural organic matter on the removal of aquatic pharmaceutical residuals by nanofiltration
This study demonstrates the removal efficiency and the permeate flux behavior during cross-
flow nanofiltration (NF) of aqueous solutions of five pharmaceutically active compounds …
flow nanofiltration (NF) of aqueous solutions of five pharmaceutically active compounds …
Review nimesulide: Some pharmaceutical and pharmacological aspects—An update
AK Singla, M Chawla, A Singh - Journal of pharmacy and …, 2000 - Wiley Online Library
Nimesulide, a non‐steroidal anti‐inflammatory drug (NSAID), is administered orally or
rectally twice daily for a variety of inflammation and pain states. This is a unique NSAID, not …
rectally twice daily for a variety of inflammation and pain states. This is a unique NSAID, not …
COX-2 in Brain and Spinal Cord-Implications for Therapeutic Use.
C Hoffmann - Current medicinal chemistry, 2000 - ingentaconnect.com
Following the discovery of inducible COX-2 in arthritic joint fluid and immunocompetent cells
a revolution in the field of antiinflammatory treatment was expected. The detection of a …
a revolution in the field of antiinflammatory treatment was expected. The detection of a …