Increased levels of tumor necrosis factor (TNF) α have been linked to a number of
pulmonary inflammatory diseases including asthma, chronic obstructive pulmonary disease …

Inflammation is a key feature in the pathogenesis of sepsis and acute respiratory distress
syndrome (ARDS). Sepsis and ARDS continue to be associated with high mortality. A key …

Asthma is a chronic inflammatory disease that undermines the airways. It is caused by
dysfunction of various types of cells, as well as cellular components, and is characterized by …

Introduction: Neutrophilic airway inflammation represents a pathologically distinct form of
asthma and frequently appears in symptomatic adulthood asthmatics. However, clinical …

Background Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both
injurious and protective functions, which are thought to diverge at the level of its two cell …

For a long time asthma was commonly considered as a homogeneous disease. However,
recent studies provide increasing evidence of its heterogeneity and existence of different …

Traditionally regarded as simple foot soldiers of the innate immune response limited to the
eradication of pathogens, neutrophils recently emerged as more complex cells endowed …

The recent classification of chronic rhinosinusitis (CRS) focusses on investigating underlying
immunopathophysiological mechanisms. Primary CRS is subdivided based on endotype …

Background: Neutrophilic asthma is generally associated with the absence of eosinophils
and activation of non-predominant type 2 immunological pathways. It involves bronchial …

Monoclonal antibodies, biologics, are a relatively new treatment option for severe chronic
airway diseases, asthma, allergic rhinitis, and chronic rhinosinusitis (CRS). In this review, we …