Zinc is an essential micronutrient, and its deficiency is perhaps the most prevalent and least
understood worldwide. Recent advances have expanded the understanding of zinc's unique …

The second abundant micronutrient, zinc, is attracting more and more attention for it
performs essential functions in living organisms and bears close relationships with the …

Abstract The Zrt-/Irt-like protein (ZIP) family consists of ubiquitously expressed divalent metal
transporters critically involved in maintaining systemic and cellular homeostasis of zinc, iron …

The zinc homeostatic proteins Zn transporter 1 (ZNT1) and metallothionein (MT) function in
dampening increases in cytosolic zinc concentrations. Conversely, the expression of ZNT1 …

Our understanding of prostate cancer (PCa) has shifted from solely caused by a few genetic
aberrations to a combination of complex biochemical dysregulations with the prostate …

Engineering of transporters to alter substrate specificity as desired holds great potential for
applications, including metabolic engineering. However, the lack of knowledge on molecular …

The essential microelement zinc is absorbed in the small intestine mainly by the zinc
transporter ZIP4, a representative member of the Zrt/Irt-like protein (ZIP) family. ZIP4 is …

Neuropathic pain affects 7–10% of the population and is often ineffectively and incompletely
treated. Although the gold standard for treatment of neuropathic pain includes tricyclic …

Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory
nervous system and affects 7–10% of the worldwide population. Neuropathic pain can be …

As an essential trace element for organisms, zinc participates in various physiological
processes, such as RNA transcription, DNA replication, cell proliferation, and cell …