Microphysiological systems to recapitulate the gut–kidney axis
L Giordano, SM Mihaila, HE Amirabadi… - Trends in …, 2021 - cell.com
Chronic kidney disease (CKD) typically appears alongside other comorbidities, highlighting
an underlying complex pathophysiology that is thought to be vastly modulated by the …
an underlying complex pathophysiology that is thought to be vastly modulated by the …
Machine learning to predict end stage kidney disease in chronic kidney disease
Q Bai, C Su, W Tang, Y Li - Scientific reports, 2022 - nature.com
The purpose of this study was to assess the feasibility of machine learning (ML) in predicting
the risk of end-stage kidney disease (ESKD) from patients with chronic kidney disease …
the risk of end-stage kidney disease (ESKD) from patients with chronic kidney disease …
[HTML][HTML] DDR1 role in fibrosis and its pharmacological targeting
S Moll, A Desmoulière, MJ Moeller, JC Pache… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Abstract Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase
and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located …
and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located …
Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: a randomised, controlled, phase 2 trial
KR Tuttle, SJ Hauske, ME Canziani, ML Caramori… - The Lancet, 2024 - thelancet.com
Background Excess aldosterone accelerates chronic kidney disease progression. This
phase 2 clinical trial assessed BI 690517, an aldosterone synthase inhibitor, for efficacy …
phase 2 clinical trial assessed BI 690517, an aldosterone synthase inhibitor, for efficacy …
Effects of Brazilian green propolis on proteinuria and renal function in patients with chronic kidney disease: a randomized, double-blind, placebo-controlled trial
Background Chronic kidney disease (CKD) is a public health problem worldwide, and
proteinuria is a well-established marker of disease progression in CKD patients. Propolis, a …
proteinuria is a well-established marker of disease progression in CKD patients. Propolis, a …
Incidence, prevalence, and duration of chronic kidney disease in Taiwan: results from a community-based screening program of 106,094 individuals
MH Tsai, CY Hsu, MY Lin, MF Yen, HH Chen, YH Chiu… - Nephron, 2018 - karger.com
Abstract Background/Aims: Taiwan has the highest incidence of end-stage renal disease,
which requires renal replacement therapy. Chronic kidney disease (CKD) contributes to this …
which requires renal replacement therapy. Chronic kidney disease (CKD) contributes to this …
DNA-encoded library-derived DDR1 inhibitor prevents fibrosis and renal function loss in a genetic mouse model of Alport syndrome
H Richter, AL Satz, M Bedoucha… - ACS chemical …, 2018 - ACS Publications
The importance of Discoidin Domain Receptor 1 (DDR1) in renal fibrosis has been shown
via gene knockout and use of antisense oligonucleotides; however, these techniques act via …
via gene knockout and use of antisense oligonucleotides; however, these techniques act via …
CircACTR2 in macrophages promotes renal fibrosis by activating macrophage inflammation and epithelial–mesenchymal transition of renal tubular epithelial cells
H Fu, YH Gu, J Tan, YN Yang, GH Wang - Cellular and Molecular Life …, 2022 - Springer
The crosstalk between macrophages and tubular epithelial cells (TECs) actively regulates
the progression of renal fibrosis. In the present study, we revealed the significance of circular …
the progression of renal fibrosis. In the present study, we revealed the significance of circular …
Intrarenal arterial administration of human umbilical cord-derived mesenchymal stem cells effectively preserved the residual renal function of diabetic kidney disease …
Y Yue, JN Yeh, JY Chiang, PH Sung, YL Chen… - Stem Cell Research & …, 2022 - Springer
Background This experimental study was designed as a preclinical study for testing the
hypothesis that intrarenal arterial (IRA) transfusion of human umbilical cord-derived …
hypothesis that intrarenal arterial (IRA) transfusion of human umbilical cord-derived …
The MEK inhibitor trametinib ameliorates kidney fibrosis by suppressing ERK1/2 and mTORC1 signaling
P Andrikopoulos, J Kieswich, S Pacheco… - Journal of the …, 2019 - journals.lww.com
Background During kidney fibrosis, a hallmark and promoter of CKD (regardless of the
underlying renal disorder leading to CKD), the extracellular-regulated kinase 1/2 (ERK1/2) …
underlying renal disorder leading to CKD), the extracellular-regulated kinase 1/2 (ERK1/2) …