Introduction: Abnormal involuntary movements often improve in response to anti-
dopaminergic drugs. In contrast to classic neuroleptics that block dopamine receptors, drugs …

Background: Several clinician, informant, and self‐report instruments for tics and associated
phenomena have been developed that differ in construct, comprehensiveness, and ease of …

Individual randomized controlled trials (RCTs) of habit reversal training and a
Comprehensive Behavioral Intervention for Tics (collectively referred to as behavior therapy …

Objectives: Aripiprazole modulates dopaminergic and serotonergic pathways that may play
a role in the pathogenesis of Tourette's disorder (TD). This trial evaluated the efficacy and …

Background Deep brain stimulation (DBS) can be an effective therapy for tics and
comorbidities in select cases of severe, treatment-refractory Tourette syndrome (TS). Clinical …

Background Deep brain stimulation (DBS) has been proposed to treat patients with severe
Tourette's syndrome, and open-label trials and two small double-blind trials have tested …

Importance Because Tourette syndrome (TS) is a paroxysmal disorder, symptomatic relief in
individuals with TS may be possible through the application of stimulation only during the …

The selection of patients with Tourette syndrome (TS) for deep brain stimulation (DBS)
surgery rests on 5 fundamental pillars. However, the operationalization of the …

Background Modulation of the endocannabinoid system via monoacylglycerol lipase
inhibition with Lu AG06466 (formerly known as ABX‐1431) has previously been shown to …

Objective To examine prospectively the association between group A Streptococcus (GAS)
pharyngeal exposures and exacerbations of tics in a large multicenter population of youth …