Structural basis of protein kinase C isoform function
SF Steinberg - Physiological reviews, 2008 - journals.physiology.org
Protein kinase C (PKC) isoforms comprise a family of lipid-activated enzymes that have
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …
Protein kinase C: poised to signal
AC Newton - American Journal of Physiology …, 2010 - journals.physiology.org
Nestled at the tip of a branch of the kinome, protein kinase C (PKC) family members are
poised to transduce signals emanating from the cell surface. Cell membranes provide the …
poised to transduce signals emanating from the cell surface. Cell membranes provide the …
[HTML][HTML] Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation
J Wang, D Gallagher, LM DeVito, GI Cancino, D Tsui… - Cell stem cell, 2012 - cell.com
Although endogenous recruitment of adult neural stem cells has been proposed as a
therapeutic strategy, clinical approaches for achieving this are lacking. Here, we show that …
therapeutic strategy, clinical approaches for achieving this are lacking. Here, we show that …
[HTML][HTML] Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
Insulin resistance and elevated glucagon levels result in nonsuppressible hepatic glucose
production and hyperglycemia in patients with type 2 diabetes. The CREB coactivator …
production and hyperglycemia in patients with type 2 diabetes. The CREB coactivator …
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
V Facchinetti, W Ouyang, H Wei, N Soto… - The EMBO …, 2008 - embopress.org
The target of rapamycin (TOR), as part of the rapamycin‐sensitive TOR complex 1 (TORC1),
regulates various aspects of protein synthesis. Whether TOR functions in this process as part …
regulates various aspects of protein synthesis. Whether TOR functions in this process as part …
AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases
JM Arencibia, D Pastor-Flores, AF Bauer… - … et Biophysica Acta (BBA …, 2013 - Elsevier
The group of AGC protein kinases includes more than 60 protein kinases in the human
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …
Crystal structure and allosteric activation of protein kinase C βII
Protein kinase C (PKC) isozymes are the paradigmatic effectors of lipid signaling. PKCs
translocate to cell membranes and are allosterically activated upon binding of the lipid …
translocate to cell membranes and are allosterically activated upon binding of the lipid …
TOR regulation of AGC kinases in yeast and mammals
E Jacinto, A Lorberg - Biochemical Journal, 2008 - portlandpress.com
The TOR (target of rapamycin), an atypical protein kinase, is evolutionarily conserved from
yeast to man. Pharmacological studies using rapamycin to inhibit TOR and yeast genetic …
yeast to man. Pharmacological studies using rapamycin to inhibit TOR and yeast genetic …
[HTML][HTML] Phosphorylation of AKT: a mutational analysis
JR Hart, PK Vogt - Oncotarget, 2011 - ncbi.nlm.nih.gov
Akt (cellular homolog of murine thymoma virus akt8 oncogene) is an essential component of
the PI3K (phosphatidylinositol 3-kinase) pathway. Its activity is stimulated by receptor …
the PI3K (phosphatidylinositol 3-kinase) pathway. Its activity is stimulated by receptor …
Regulation of protein kinase C function by phosphorylation on conserved and non-conserved sites
M Freeley, D Kelleher, A Long - Cellular signalling, 2011 - Elsevier
Protein Kinase C (PKC) is a family of serine/threonine kinases whose function is influenced
by phosphorylation. In particular, three conserved phosphorylation sites known as the …
by phosphorylation. In particular, three conserved phosphorylation sites known as the …