Amyloidosis is a pathologic and clinical condition resulting from the accumulation of
insoluble aggregates of misfolded proteins in tissues. Extracellular deposition of amyloid …

Transthyretin cardiac amyloidosis (ATTR-CA) is a progressive disease characterized by the
deposition of abnormal transthyretin protein fibrils in the heart, leading to cardiac …

The mechanisms of tissue damage in kidney amyloidosis are not well described. To
investigate this further, we used laser microdissection-mass spectrometry to identify proteins …

Amyloidosis is a disease caused by pathological fibril aggregation and deposition of
proteins in different tissues and organs. Thirty-six fibril-forming proteins have been identified …

Population aging is one of the most important demographic transformations of our time.
Increasing the “health span”—the proportion of life spent in good health—is a global priority …

The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological
complications in patients, known as long COVID, have renewed the interest in the …

The deposition of amyloid light chains (LCs) in target sites translates into tissue damage and
organ dysfunction. Clinical and experimental advances have cast new light on the …

AL amyloidosis is caused by the misfolding of immunoglobulin light chains leading to an
impaired function of tissues and organs in which they accumulate. Due to the paucity of …

Background: Immunoglobulin derived AL amyloidosis and transthyretin derived ATTR
amyloidosis are the most common forms of cardiac amyloidosis. Both may present with …

Aims To compare the baseline cardiovascular characteristics of immunoglobulin light-chain
(AL) and amyloid transthyretin (ATTR) cardiac amyloidosis (CA) and to investigate patients' …