Heart failure is considered an epidemic disease in the modern world affecting approximately
1% to 2% of adult population. It presents a multifactorial, systemic disease, in which—after …

The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the
natural pacemaker of the heart, making it responsible for initiating each-and-every normal …

α1-Adrenergic receptors (ARs) are catecholamine-activated G protein-coupled receptors
(GPCRs) that are expressed in mouse and human myocardium and vasculature, and play …

Most pharmaceutical companies test their discovery-stage proprietary molecules in a battery
of in vitro pharmacology assays to try to determine off-target interactions. During all phases …

Hyperactivity of the sympathetic nervous system is a major driver of cardiac remodeling,
exerting its effects through both α-, and β-adrenoceptors (α-, β-ARs). As the relative …

Summary Alpha-1 adrenergic receptors (α1-ARs) play adaptive and protective roles in the
heart. Dabuzalgron is an oral selective α1A-AR agonist that was well tolerated in multiple …

It has been well established that histone and DNA modifications are critical to maintaining
the equilibrium between pluripotency and differentiation during early embryogenesis …

Abnormal mitochondrial morphology, especially fragmented mitochondria, and
mitochondrial dysfunction are hallmarks of a variety of human diseases including heart …

Heart and blood vessels ensure adequate perfusion of peripheral organs with blood and
nutrients. Alteration of the homeostatic functions of the cardiovascular system can cause …

Objective To evaluate the effects of progressively increasing doses of acepromazine on
cardiopulmonary variables and sedation in conscious dogs. Study design Prospective …