Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1
Dichloroacetate (DCA) has several therapeutic applications based on its pharmacological
property of inhibiting pyruvate dehydrogenase kinase. DCA has been used to treat inherited …
property of inhibiting pyruvate dehydrogenase kinase. DCA has been used to treat inherited …
Glutathione S-transferase π: a potential role in antitumor therapy
SC Dong, HH Sha, XY Xu, TM Hu, R Lou… - Drug design …, 2018 - Taylor & Francis
Glutathione S-transferase π (GSTπ) is a Phase II metabolic enzyme that is an important
facilitator of cellular detoxification. Traditional dogma asserts that GSTπ functions to catalyze …
facilitator of cellular detoxification. Traditional dogma asserts that GSTπ functions to catalyze …
Clinical physiology and pharmacology of GSTZ1/MAAI
PW Stacpoole - Biochemical Pharmacology, 2023 - Elsevier
Herein I summarize the physiological chemistry and pharmacology of the bifunctional
enzyme glutathione transferase zeta 1 (GSTZ1)/maleylacetoacetate isomerase (MAAI) …
enzyme glutathione transferase zeta 1 (GSTZ1)/maleylacetoacetate isomerase (MAAI) …
Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity
H Komatsu, H Takeuchi, Y Kikuchi, C Ono… - Schizophrenia …, 2020 - academic.oup.com
Previous studies have indicated associations between several OLIG2 gene single-
nucleotide polymorphisms (SNPs) and susceptibility to schizophrenia among Caucasians …
nucleotide polymorphisms (SNPs) and susceptibility to schizophrenia among Caucasians …
Pharmacogenetic considerations with dichloroacetate dosing
MO James, PW Stacpoole - Pharmacogenomics, 2016 - Taylor & Francis
The investigational drug dichloroacetate (DCA) is a metabolic regulator that has been
successfully used to treat acquired and congenital metabolic diseases and, recently, solid …
successfully used to treat acquired and congenital metabolic diseases and, recently, solid …
GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial
DD Tian, SK Bennett, LA Coupland… - Pharmacology …, 2019 - Wiley Online Library
Dichloroacetate (DCA) is an investigational drug targeting the glycolytic hallmark of cancer
by inhibiting pyruvate dehydrogenase kinases (PDK). It is metabolized by GSTZ1, which has …
by inhibiting pyruvate dehydrogenase kinases (PDK). It is metabolized by GSTZ1, which has …
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate
SC Jahn, MHM Solayman, RJ Lorenzo… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Dichloroacetate (DCA), commonly used to treat metabolic disorders, is under investigation
as an anti-cancer therapy due to its ability to reverse the Warburg effect and induce …
as an anti-cancer therapy due to its ability to reverse the Warburg effect and induce …
Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes
B Zhou, P Yang, YJ Gong, Q Zeng, WQ Lu… - Environmental Pollution, 2018 - Elsevier
Background Prenatal disinfection by-products (DBPs) exposure is linked with adverse birth
outcomes. Genetic susceptibility to DBP metabolism may modify the exposure-outcome …
outcomes. Genetic susceptibility to DBP metabolism may modify the exposure-outcome …
Neuroprotective Effects and Therapeutic Potential of Dichloroacetate: Targeting Metabolic Disorders in Nervous System Diseases
Y Zhang, M Sun, H Zhao, Z Wang, Y Shi… - International Journal …, 2023 - Taylor & Francis
Dichloroacetate (DCA) is an investigational drug used to treat lactic acidosis and malignant
tumours. It works by inhibiting pyruvate dehydrogenase kinase and increasing the rate of …
tumours. It works by inhibiting pyruvate dehydrogenase kinase and increasing the rate of …
Interactions between CYP2E1, GSTZ1 and GSTT1 polymorphisms and exposure to drinking water trihalomethanes and their association with semen quality
P Yang, Q Zeng, WC Cao, YX Wang, Z Huang, J Li… - Environmental …, 2016 - Elsevier
Trihalomethanes (THMs) have been reported to be associated with altered semen quality,
and this association may be modified by inherited differences in cytochrome P450 (CYP2E1) …
and this association may be modified by inherited differences in cytochrome P450 (CYP2E1) …