Background Patients with lower extremity peripheral arterial disease (PAD) and sarcopenia
are a population at risk requiring specific and targeted care. The aim of this review is to …

Peripheral artery disease (PAD) is a common circulatory disorder of the lower limb arteries
that reduces functional capacity and quality of life of patients. Despite relatively effective …

Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease
(PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated …

Significance: Oxidative stress contributes to numerous pathophysiological conditions such
as development of cancer, neurodegenerative, and cardiovascular diseases. A variety of …

Reactive oxygen and nitrogen species (ROS and RNS, eg H 2 O 2, nitric oxide) confer redox
regulation of essential cellular signaling pathways such as cell differentiation, proliferation …

Emerging evidence suggests that neuroinflammation and oxidative stress may be major
contributors to major depressive disorder (MDD). Patients or animal models of depression …

Rationale: Klf (kruppel-like factor) 2 is critical to establish and maintain endothelial integrity.
Objective: Therefore, determining upstream and downstream mediators of Klf2 would lead to …

Peripheral arterial disease (PAD) is a frequent and serious condition, potentially life-
threatening and leading to lower-limb amputation. Its pathophysiology is generally related to …

Muscle injury resulting from ischemia-reperfusion largely aggravates patient prognosis but
whether and how muscle phenotype modulates ischemia-reperfusion-induced mitochondrial …

Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia,
promotes the formation of atheromatous plaques in large vessels of the cardiovascular …