The past 25 years of genomics research first revealed which genes are encoded by the
human genome and then a detailed catalogue of human genome variation associated with …

CRISPR-based technologies represent a major breakthrough in biomedical science as they
offer a powerful platform for unbiased screening and functional genomics in various fields …

Ferredoxins are a family of iron–sulfur (Fe-S) cluster proteins that serve as essential electron
donors in numerous cellular processes that are conserved through evolution. The …

Interplay between chromatin-associated complexes and modifications critically contribute to
the partitioning of epigenome into stable and functionally distinct domains. Yet there is a lack …

The sterol regulatory element binding proteins (SREBPs) are transcription factors that
govern cholesterol and fatty acid metabolism. We recently identified SPRING as a post …

Lipid metabolism reprogramming is an important hallmark of tumor progression. Cancer
cells require high levels of lipid synthesis and uptake not only to support their continued …

Recurrent loss-of-function deletions cause frequent inactivation of tumour suppressor genes
but often also involve the collateral deletion of essential genes in chromosomal proximity …

CRISPR knockout fitness screens in cancer cell lines reveal many genes whose loss of
function causes cell death or loss of fitness or, more rarely, the opposite phenotype of faster …

Abstract The mannose-6-phosphate (M6P) biosynthetic pathway for lysosome biogenesis
has been studied for decades and is considered a well-understood topic. However, whether …

We report here two genome-wide CRISPR screens performed to identify genes that, when
knocked out, alter levels of lysosomal cholesterol or bis (monoacylglycero) phosphate. In …