Objective To amass all available evidence regarding the safety of intravenous (IV) iron
preparations to provide a true balance of efficacy and safety. Methods Systematic review …

Impaired iron homeostasis and the suppressive effects of proinflammatory cytokines on
erythropoiesis, together with alterations of the erythrocyte membrane that impair its survival …

Importance Intravenous iron is recommended by many clinical guidelines based largely on
its effectiveness in reducing anemia. However, the association with important safety …

Objective To develop evidence-based clinical practice recommendations regarding
transfusion practices in non-bleeding, critically ill adults. Design A task force involving 13 …

ContextAnemia is a common problem in critically ill patients admitted to intensive care units
(ICUs), but the consequences of anemia on morbidity and mortality in the critically ill is …

Despite numerous guidelines on the management of anaemia in surgical patients, there is
no pragmatic guidance for the diagnosis and management of anaemia and iron deficiency in …

Objectives To evaluate the efficacy and safety of intravenous iron, focusing primarily on its
effects on haemoglobin, requirement for transfusion, and risk of infection. Design Systematic …

Objective To quantify the incidence of anemia and red blood cell (RBC) transfusion practice
in critically ill patients and to examine the relationship of anemia and RBC transfusion to …

Iron is an essential micronutrient, as it is required for adequate erythropoietic function,
oxidative metabolism and cellular immune responses. Although the absorption of dietary …

Iron transport in the plasma is carried out by transferrin, which donates iron to cells through
its interaction with a specific membrane receptor, the transferrin receptor (TfR). A soluble …