Irisin, out-membrane part of fibronectin type III domain–containing 5 protein (FNDC5), was
activated by Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) …

Polycystic ovary syndrome (PCOS) is a multifaceted condition characterized by chronic
anovulation and excess ovarian activity, in contrast to other causes of anovulation that …

Aerobic exercise involves in ameliorating kidney injury, but the underlying mechanisms are
not fully clarified. In this study, we elucidated the potential mechanisms of aerobic exercise …

Exercise is a well-known non-pharmacological intervention to improve brain functions,
including cognition, memory, and motor coordination. Contraction of skeletal muscles during …

Irisin is a muscle-secreted hormone that is generated by cleavage of membrane protein
FNDC-5 (fibronectin type III domain-containing protein 5). Irisin is considered to be a …

Physical exercise may improve cognitive function by modulating molecular and cellular
mechanisms within the brain. We propose that the facilitation of long-term synaptic …

Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with insulin resistance
and hyperglycemia. Chronic exposure to a T2DM microenvironment with hyperglycemia …

Aging is a progressive process leading to functional decline in many domains. Recent
studies have shown that physical exercise (PE) has a positive influence on the progression …

Significance: The prevalence and incidence of age-related neurodegenerative diseases
(NDDs) tend to increase along with the enhanced average of the world life expectancy …

The beneficial effects of exercise on human brain function have been demonstrated in
previous studies. Myokines secreted by muscle have attracted increasing attention because …