It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating
illness of major significance throughout Latin America and an emergent threat to global …

Although the genome of Trypanosoma cruzi, the causative agent of Chagas disease, was
first made available in 2005, with additional strains reported later, the intrinsic genome …

Vector-borne illnesses comprise a significant portion of human maladies, representing 17%
of global infections. Transmission of vector-borne pathogens to mammals primarily occurs …

Between-sample normalization is a critical step in genomic data analysis to remove
systematic bias and unwanted technical variation in high-throughput data. Global …

Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus
Leishmania, form a group of flagellated protists that threaten human health. These …

In nearly all eukaryotes, cellular differentiation is governed by changes in transcription, and
stabilized by chromatin and DNA modification. Gene expression control in the pathogen …

Leishmaniasis (Leishmania species), sleeping sickness (Trypanosoma brucei), and Chagas
disease (Trypanosoma cruzi) are devastating and globally spread diseases caused by …

Obligate intracellular pathogens satisfy their nutrient requirements by coupling to host
metabolic processes, often modulating these pathways to facilitate access to key …

Trypanosoma cruzi, the protozoan that causes Chagas disease, has a complex life cycle
involving several morphologically and biochemically distinct stages that establish intricate …