Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies

AL Mueller, Z Payandeh, N Mohammadkhani… - Cells, 2021 - mdpi.com
Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4

X Zhou, S Kong, A Maker, SG Remesh… - Nature Chemical …, 2024 - nature.com
Unlocking the potential of protein arginine deiminase 4 (PAD4) as a drug target for
rheumatoid arthritis requires a deeper understanding of its regulation. In this study, we use …

Autoantibodies to protein-arginine deiminase (PAD) 4 in rheumatoid arthritis: immunological and clinical significance, and potential for precision medicine: Anti-PAD4 …

L Martinez-Prat, B Palterer, G Vitiello… - Expert review of …, 2019 - Taylor & Francis
Introduction: The protein-arginine deiminase (PAD) 4 enzyme plays an important role in the
pathogenesis of rheumatoid arthritis (RA) and also represents an antigenic target. Anti …

Sinomenine ameliorates adjuvant-induced arthritis by inhibiting the autophagy/NETosis/inflammation axis

H Jiang, Q Lu, J Xu, G Huo, Y Cai, S Geng, H Xu… - Scientific Reports, 2023 - nature.com
Studies have found that neutrophil extracellular traps (NETs) which are the specific dying
form of neutrophil upon activation have fundamental role in the rheumatoid arthritis onset …

Andrographolide ameliorates rheumatoid arthritis by regulating the apoptosis–NETosis balance of neutrophils

X Li, K Yuan, Q Zhu, Q Lu, H Jiang, M Zhu… - International journal of …, 2019 - mdpi.com
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by symmetric
polyarthritis with swelling and pain at synovial joints. In RA patients, delayed neutrophil …

[HTML][HTML] Regulating neutrophil PAD4/NOX-dependent cerebrovasular thromboinflammation

J Ansari, SA Vital, S Yadav… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Background: Neutrophil extracellular trap (NET) production has been implicated in the
pathogenesis of thromboinflammatory conditions such as Sickle Cell Disease (SCD) …

Tetrandrine ameliorates rheumatoid arthritis in mice by alleviating neutrophil activities

Q Lu, H Jiang, Q Zhu, J Xu, Y Cai, G Huo… - Evidence‐Based …, 2022 - Wiley Online Library
Rheumatoid arthritis (RA) is a common autoimmune disease worldwide. Neutrophils play
critical roles in the onset and development of RA and are the promising target for RA …

PADI4 promotes epithelial-mesenchymal transition (EMT) in gastric cancer via the upregulation of interleukin 8

X Chang, H Wu, H Li, H Li, Y Zheng - Bmc Gastroenterology, 2022 - Springer
Background Gastric cancer (GC) is one of the deadliest tumours due to its ability to
metastasize. The Epithelial–to-mesenchymal transition plays a crucial role in promoting the …

Neutrophil extracellular traps in rheumatoid arthritis and periodontitis: Contribution of PADI4 gene polymorphisms

SR Oliveira, JAA de Arruda… - Journal of Clinical …, 2024 - Wiley Online Library
Aim We sought to investigate the release of neutrophil extracellular traps (NETs) in
neutrophils from individuals with rheumatoid arthritis (RA) and controls and compare the …

Novel autoantibodies related to cell death and DNA repair pathways in systemic lupus erythematosus

H Luo, L Wang, D Bao, L Wang, H Zhao… - Genomics …, 2019 - academic.oup.com
Systemic lupus erythematosus (SLE) is a complex autoimmune syndrome characterized by
various co-existing autoantibodies (autoAbs) in patients' blood. However, the full spectrum of …