Next generation sequencing and bioinformatics methodologies for infectious disease research and public health: approaches, applications, and considerations for …

I Maljkovic Berry, MC Melendrez… - The Journal of …, 2020 - academic.oup.com
Next generation sequencing (NGS) combined with bioinformatics has successfully been
used in a vast array of analyses for infectious disease research of public health relevance …

Emerging and reemerging neglected tropical diseases: a review of key characteristics, risk factors, and the policy and innovation environment

TK Mackey, BA Liang, R Cuomo, R Hafen… - Clinical microbiology …, 2014 - Am Soc Microbiol
In global health, critical challenges have arisen from infectious diseases, including the
emergence and reemergence of old and new infectious diseases. Emergence and …

Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease

LA Messenger, MA Miles, C Bern - Expert review of anti-infective …, 2015 - Taylor & Francis
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …

Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution

DA Maslov, FR Opperdoes, AY Kostygov, H Hashimi… - Parasitology, 2019 - cambridge.org
Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Next generation sequencing: implications in personalized medicine and pharmacogenomics

B Rabbani, H Nakaoka, S Akhondzadeh… - Molecular …, 2016 - pubs.rsc.org
A breakthrough in next generation sequencing (NGS) in the last decade provided an
unprecedented opportunity to investigate genetic variations in humans and their roles in …

Hybridization in parasites: consequences for adaptive evolution, pathogenesis, and public health in a changing world

KC King, RB Stelkens, JP Webster, DF Smith… - PLoS …, 2015 - journals.plos.org
Hybridization of parasites is an emerging public health concern at the interface of infectious
disease biology and evolution. Increasing economic development, human migration, global …

Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts

LJ Morrison, PC Steketee, MD Tettey, KR Matthews - Virulence, 2023 - Taylor & Francis
African trypanosomes are vector-borne protozoa, which cause significant human and animal
disease across sub-Saharan Africa, and animal disease across Asia and South America. In …

Population genomics reveals the origin and asexual evolution of human infective trypanosomes

W Weir, P Capewell, B Foth, C Clucas, A Pountain… - elife, 2016 - elifesciences.org
Evolutionary theory predicts that the lack of recombination and chromosomal re-assortment
in strictly asexual organisms results in homologous chromosomes irreversibly accumulating …

Colonization and genetic diversification processes of Leishmania infantum in the Americas

P Schwabl, MC Boité, G Bussotti, A Jacobs… - Communications …, 2021 - nature.com
Leishmania infantum causes visceral leishmaniasis, a deadly vector-borne disease
introduced to the Americas during the colonial era. This non-native trypanosomatid parasite …

Admixture in Humans of Two Divergent Plasmodium knowlesi Populations Associated with Different Macaque Host Species

PCS Divis, B Singh, F Anderios, S Hisam… - PLoS …, 2015 - journals.plos.org
Human malaria parasite species were originally acquired from other primate hosts and
subsequently became endemic, then spread throughout large parts of the world. A major …