[HTML][HTML] From animal poisons and venoms to medicines: achievements, challenges and perspectives in drug discovery

KCF Bordon, CT Cologna, EC Fornari-Baldo… - Frontiers in …, 2020 - frontiersin.org
Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …

[HTML][HTML] Bee updated: current knowledge on bee venom and bee envenoming therapy

MB Pucca, FA Cerni, IS Oliveira, TP Jenkins… - Frontiers in …, 2019 - frontiersin.org
Honey bees can be found all around the world and fulfill key pollination roles within their
natural ecosystems, as well as in agriculture. Most species are typically docile, and most …

[HTML][HTML] The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins

K Suryamohan, SP Krishnankutty, J Guillory, M Jevit… - Nature Genetics, 2020 - nature.com
Snakebite envenoming is a serious and neglected tropical disease that kills~ 100,000
people annually. High-quality, genome-enabled comprehensive characterization of toxin …

A current perspective on snake venom composition and constituent protein families

T Tasoulis, GK Isbister - Archives of toxicology, 2023 - Springer
Snake venoms are heterogeneous mixtures of proteins and peptides used for prey
subjugation. With modern proteomics there has been a rapid expansion in our knowledge of …

[HTML][HTML] Old World Vipers—a review about snake venom proteomics of Viperinae and their variations

M Damm, BF Hempel, RD Süssmuth - Toxins, 2021 - mdpi.com
Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …

[HTML][HTML] Innovative immunization strategies for antivenom development

E Bermúdez-Méndez, A Fuglsang-Madsen, S Føns… - Toxins, 2018 - mdpi.com
Snakes, scorpions, and spiders are venomous animals that pose a threat to human health,
and severe envenomings from the bites or stings of these animals must be treated with …

[HTML][HTML] Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations

AAX Adrião, AO Dos Santos, EJSP de Lima… - Frontiers in …, 2022 - frontiersin.org
Snakebite envenomations (SBEs) are a neglected medical condition of global importance
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …

[HTML][HTML] Hypotensive snake venom components—a mini-review

O Péterfi, F Boda, Z Szabó, E Ferencz, L Bába - Molecules, 2019 - mdpi.com
Hypertension is considered a major public health issue due to its high prevalence and
subsequent risk of cardiovascular and kidney diseases. Thus, the search for new …

Venomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera Vipera, Montivipera, Macrovipera, and Daboia across …

M Damm, M Karış, D Petras… - Journal of Proteome …, 2024 - ACS Publications
Snake venom variations are a crucial factor to understand the consequences of snakebite
envenoming worldwide, and therefore it is important to know about toxin composition …

Computer-aided design of lasso-like self-assembling anticancer peptides with multiple functions for targeted self-delivery and cancer treatments

P Pei, L Chen, R Fan, XR Zhou, S Feng, H Liu, Q Guo… - ACS …, 2022 - ACS Publications
Anticancer peptides are promising drug candidates for cancer treatment, but the short
circulation time and low delivery efficiency limit their clinical applications. Herein, we …