To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

The circadian timing system synchronizes cellular function by coordinating rhythmic
transcription via a transcription-translational feedback loop. How the circadian system …

A genetic screen for mutants that alter circadian rhythms in Drosophila identified the first
clock gene—the period (per) gene. The per gene is a central player within a transcriptional …

Terrestrial organisms developed circadian rhythms for adaptation to Earth's quasi-24-h
rotation. Achieving precise rhythms requires diurnal oscillation of fundamental biological …

Highlights•Work on circadian period determination and output gene regulation are
reviewed.•Clock protein glycosylation, ubiquitylation and translation influence 24 hours …

Locomotor activity rhythms are controlled by a network of~ 150 circadian neurons within the
adult Drosophila brain. They are subdivided based on their anatomical locations and …

Eukaryotic circadian clocks include transcriptional/translational feedback loops that drive 24-
h rhythms of transcription. These transcriptional rhythms underlie oscillations of protein …

Circadian clocks temporally organize behavior and physiology across the 24-h day. Great
progress has been made in understanding the molecular basis of timekeeping, with a focus …

Evidence for transcriptional feedback in circadian timekeeping is abundant, yet little is
known about the mechanisms underlying translational control. We found that ATAXIN-2 …