Ischemia induces a variety of cellular metabolic and ultrastructural changes promoting
expression of proinflammatory gene products eg cytokines, while repressing protective gene …

The field of myocardial regeneration (angiogenesis and myogenesis) might prove to play an
important role in the future management of cardiovascular disease. Stem cells are currently …

Objectives: The purpose of this study was to test the ability of insulin-like growth factor (IGF)-
1/hepatocyte growth factor (HGF) to activate resident endogenous porcine cardiac …

Abstract Insulin-like growth factor-1 (IGF-1) has demonstrated beneficial effects after
myocardial infarction (MI). Microencapsulation of IGF-1 could potentially improve results. We …

Cardiovascular diseases are a major health concern and therefore an important topic in
biomedical research. Large animal models allow researchers to assess the safety and …

There are several experimental models for the in vivo investigation of myocardial infarction
(MI) in small (mouse, rat) and large animals (dog, pig, sheep and baboons). The application …

Aims Ischemic myocardial injury leads to the activation of inflammatory mechanisms and
results in ventricular remodeling. Although great efforts have been made to unravel the …

Background The optimal delivery route to enhance effectiveness of regenerative
therapeutics to the human heart is poorly understood. Direct intra-myocardial (IM) injection is …

Acute coronary occlusion is effectively treated by primary percutaneous coronary
intervention. However, myocardial ischemia–reperfusion injury is at the moment an …

Our aim was to develop an easy‐to‐induce, reproducible, and low mortality clinically
relevant closed‐chest model of chronic myocardial infarction in swine using intracoronary …