▪ Abstract Adenosine is a modulator that has a pervasive and generally inhibitory effect on
neuronal activity. Tonic activation of adenosine receptors by adenosine that is normally …

Adenosine has several functions within the CNS that involve an inhibitory tone of
neurotransmission and neuroprotective actions in pathological conditions. The …

Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic
modulator and also as a neuromodulator at the synaptic level. We will present evidence to …

It is generally thought that neuronal death caused by a reduction in oxygen or glucose
supply, or both, occurs as a result of massive increases in the extracellular concentrations of …

There are multiple mechanisms by which adenine nucleotides can be released into the
extracellular space in brain. Adenine nucleotides are converted extracellularly to adenosine …

Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …

Eighty years ago Drury & Szent-Gyorgyi described the actions of adenosine, AMP (adenylic
acid) and ATP (pyrophosphoric or diphosphoric ester of adenylic acid) on the mammalian …

Now there is general agreement that the purine nucleoside adenosine is an important
neuromodulator in the central nervous system, playing a crucial role in neuronal excitability …

Direct measurement of adenosine release during hypoxia in the CA1 region of the rat
hippocampal slice - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

In acute ischaemic brain injury and chronic neurodegeneration, the first step leading to
excitotoxicity and cell death is the excessive release of Glu and the prolonged activation of …