Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …

Human adenovirus (HAdV) is a ubiquitous virus that infects the mucosa of the eye. It is the
most common cause of infectious conjunctivitis worldwide, affecting people of all ages and …

The repositioning of drugs already approved by regulatory agencies for other indications is
an emerging alternative for the development of new antimicrobial therapies. The …

Since time immemorial human beings have constantly been fighting against viral infections.
The ongoing and devastating coronavirus disease 2019 pandemic represents one of the …

Apobec3A is involved in the antiviral host defense, targeting nuclear DNA, introducing point
mutations, and thereby activating DNA damage response (DDR). Here, we found a …

Multiple multicomponent reactions rapidly assemble complex structures. Despite being very
productive, the lack of selectivity and the reduced number of viable transformations restrict …

The effective treatment of adenovirus (HAdV) infections in immunocompromised patients still
poses great challenges. Herein, we reported our continued efforts to optimize a series of …

PML nuclear bodies are matrix-bound nuclear structures with a variety of functions in human
cells. These nuclear domains are interferon regulated and play an essential role during virus …

The repurposing of drugs approved by the regulatory agencies for other indications is
emerging as a valuable alternative for the development of new antimicrobial therapies …

Human adenovirus (HAdV) infection is a major cause of respiratory disease, yet no antiviral
drugs have been approved for its treatment. Herein, we evaluated the antiviral and anti …