Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …

Retinoblastoma (RB) is the most common intraocular malignancy in childhood.
Approximately 40% of retinoblastomas are hereditary and due to germline mutations in the …

Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to
preserve life, with ocular survival, visual preservation and quality of life as secondary aims …

Rare hereditary disorders provide unequivocal evidence of the importance of genes in
human disease pathogenesis. Familial syndromes that predispose to osteosarcomagenesis …

Osteosarcoma (OS) is the most common malignant bone tumor in children. Despite efforts to
develop and implement new therapies, patient outcomes have not measurably improved …

Cancer immunotherapy has emerged as a novel anti-tumor treatment. Despite significant
breakthroughs, cancer immunotherapy remains focused on several types of tumors that are …

The RB1 gene is frequently mutated in human cancers but its role in tumorigenesis remains
incompletely defined. Using an induced pluripotent stem cell (iPSC) model of hereditary …

Despite major advancements in cancer treatments, there are still many limitations to therapy
including off-target effects, drug resistance, and control of cancer-related symptoms. There …

Dysregulation of the CXCL12/CXCR4 axis is implicated in autoimmune, inflammatory, and
oncogenic diseases, positioning CXCR4 as a pivotal therapeutic target. We evaluated …

Retinoblastoma is a rare cancer in children, where in less than a century of dire mortality
there has been a cure in industrialized countries. Unfortunately, mortality remains high in …