Gastroesophageal reflux (GER) is commonly observed in children, particularly during the
first year of life. Pharmacological therapy is mostly reserved for symptomatic infants …

Gastroesophageal reflux is a common phenomenon in infants, but the differentiation
between gastroesophageal reflux and gastroesophageal reflux disease can be difficult …

OBJECTIVE: there are many questions and little evidence regarding the diagnosis and
treatment of gastroesophageal reflux disease (GERD) in children. The association between …

Pediatric physiologically based pharmacokinetic (PBPK) models facilitate the estimation of
pharmacokinetic (PK) parameters in children under specific exposure conditions. In human …

The objective of this study was to develop pediatric physiologically based pharmacokinetic
(PBPK) models for pantoprazole and esomeprazole. Pediatric PBPK models were …

Objectives: Food and Drug Administration approval of proton-pump inhibitors for infantile
gastroesophageal reflux disease has been limited by intrapatient variability in the clinical …

Objective. Commonly recommended drugs for adults and children include proton pump
inhibitors (PPIs), proven effective for treating peptic diseases like stomach ulcers, GERD …

OBJECTIVE: there are many questions and little evidence regarding the diagnosis and
treatment of gastroesophageal reflux disease (GERD) in children. The association between …

Inter-individual variation in pharmacokinetic parameters of drugs can have profound effects
on drug safety in children. Midazolam and morphine are among the most commonly used …

Introduction: A common diagnostic entity in children is Esophagitis with multiple etiologies
and complex immuno-pathogenic mechanisms. Our understanding of these mechanisms …