Many systems on our planet shift abruptly and irreversibly from the desired state to an
undesired state when forced across a “tipping point”. Some examples are mass extinctions …

Metabolism is generally considered as a neatly organised system of modular pathways,
shaped by evolution under selection for optimal cellular growth. This view falls short of …

Phenotypic (non-genetic) heterogeneity has significant implications for the development and
evolution of organs, organisms, and populations. Recent observations in multiple cancers …

Multistationarity in molecular systems underlies switch-like responses in cellular decision
making. Determining whether and when a system displays multistationarity is in general a …

Biochemical systems that express certain chemical species of interest at the same level at
any positive steady state are called 'absolute concentration robust'(ACR). These species …

The multiple futile cycle is a phosphorylation system in which a molecular substrate might be
phosphorylated sequentially n times by means of an enzymatic mechanism. The system has …

Background Theoretical analysis of signaling pathways can provide a substantial amount of
insight into their function. One particular area of research considers signaling pathways …

Recent breakthroughs in deep learning have revolutionized protein sequence and structure
prediction. These advancements are built on decades of protein design efforts, and are …

Abrupt shifts between alternative regimes occur in complex systems, from cell regulation to
brain functions to ecosystems. Several model-free early warning signals (EWS) have been …

Deciding whether and where a system of parametrized ordinary differential equations
displays bistability, that is, has at least two asymptotically stable steady states for some …