IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the
formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and …

IQGAP1 is a scaffolding protein that binds to a diverse array of signalling and structural
molecules. By interacting with its target proteins, human IQGAP1 participates in multiple …

Microscopy of fluorescent fusion proteins and genetic dependencies show that fission yeast
assemble and constrict a cytokinetic contractile ring in a precisely timed, sequential order …

Polyploidy, recognized by multiple copies of the haploid chromosome number, has been
described in plants, insects, and in mammalian cells such as, the platelet precursors, the …

Early observations of centrosomes, made a century ago, revealed a tiny dark structure
surrounded by a radial array of cytoplasmic fibers. We now know that the fibers are …

Cytokinesis is the final event of the cell division cycle, and its completion results in
irreversible partition of a mother cell into two daughter cells. Cytokinesis was one of the first …

Objective. Polyploidy, the state of having greater than the diploid content of DNA, has been
recognized in a variety cells. Among these cell types, the megakaryocytes are classified as …

The contractile ring is essential for cytokinesis in most fungal and animal cells. In fission
yeast, cytokinesis nodes are precursors of the contractile ring and mark the future cleavage …

Unlike ubiquitin, the ubiquitin-like protein modifier SUMO-1 and its budding yeast
homologue Smt3p have been shown to be more important for posttranslational protein …

Background: Inhibitor of apoptosis proteins (IAPs) suppress apoptotic cell death in several
model systems and are highly conserved between insects and mammals. All IAPs contain at …