This review covers recent advances in understanding the molecular mechanisms controlling
neurogenesis and specification of the developing retina, with a focus on insights obtained …

The spinal cord has been used as a model to dissect the mechanisms that govern the
patterning of tissues during animal development, since the principles that rule the dorso …

The creation of molecular tools able to unravel in vivo spatiotemporal activation of specific
cell signaling events during cell migration, differentiation and morphogenesis is of great …

Background The zebrafish retina maintains two populations of stem cells: first, the germinal
zone or ciliary marginal zone (CMZ) contains multipotent retinal progenitors that add cells to …

The mature, functional, and healthy eye is generated by the coordinated regulatory
interaction of numerous and diverse developing tissues. The neural retina of the eye must …

Wnt/β-catenin signaling is highly active in the dorsal retinal pigment epithelium (RPE) during
eye development. To study the role of Wnt/β-catenin signaling in the RPE development we …

The vertebrate eye is a highly specialized sensory organ, which is derived from the anterior
neural plate, head surface ectoderm, and neural crest-derived mesenchyme. The single …

Human pluripotent stem cells (PSCs) represent a powerful tool to investigate human eye
development and disease. When grown in 3D, they can self-assemble into laminar …

Secreted frizzled-related proteins (Sfrps) are considered Wnt signalling antagonists but
recent studies have shown that specific family members enhance Wnt diffusion and thus …

Bone morphogenic protein (BMP) signaling is fundamental to development, injury response,
and homeostasis. We have developed transgenic zebrafish that report Smad‐mediated BMP …