Unveiling the complexity of transcription factor networks in hematopoietic stem cells: implications for cell therapy and hematological malignancies
A Benyoucef, JJ Haigh, M Brand - Frontiers in Oncology, 2023 - frontiersin.org
The functionality and longevity of hematopoietic tissue is ensured by a tightly controlled
balance between self-renewal, quiescence, and differentiation of hematopoietic stem cells …
balance between self-renewal, quiescence, and differentiation of hematopoietic stem cells …
Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis
Y Li, Z Liao, H Luo, A Benyoucef, Y Kang… - Nucleic acids …, 2020 - academic.oup.com
Aberrant activation of the TAL1 is associated with up to 60% of T-ALL cases and is involved
in CTCF-mediated genome organization within the TAL1 locus, suggesting that CTCF …
in CTCF-mediated genome organization within the TAL1 locus, suggesting that CTCF …
Endothelial gene regulatory elements associated with cardiopharyngeal lineage differentiation
I Aurigemma, O Lanzetta, A Cirino, S Allegretti… - Communications …, 2024 - nature.com
Endothelial cells (EC) differentiate from multiple sources, including the cardiopharyngeal
mesoderm, which gives rise also to cardiac and branchiomeric muscles. The enhancers …
mesoderm, which gives rise also to cardiac and branchiomeric muscles. The enhancers …
Single site-specific integration targeting coupled with embryonic stem cell differentiation provides a high-throughput alternative to in vivo enhancer analyses
AC Wilkinson, DK Goode, YH Cheng… - Biology …, 2013 - journals.biologists.com
Comprehensive analysis of cis-regulatory elements is key to understanding the dynamic
gene regulatory networks that control embryonic development. While transgenic animals …
gene regulatory networks that control embryonic development. While transgenic animals …
[HTML][HTML] Transcriptional regulation of Hhex in hematopoiesis and hematopoietic stem cell ontogeny
RP Migueles, L Shaw, NP Rodrigues, G May… - Developmental …, 2017 - Elsevier
Hematopoietic stem cells (HSCs) emerge during development via an endothelial-to-
hematopoietic transition from hemogenic endothelium of the dorsal aorta (DA). Using in situ …
hematopoietic transition from hemogenic endothelium of the dorsal aorta (DA). Using in situ …
Chemokine SDF1 Mediated Bone Regeneration Using Biodegradable Poly(D,L-lactide-co-glycolide) 3D Scaffolds and Bone Marrow-Derived Mesenchymal Stem …
There is an increasing need for bone substitutes for reconstructive orthopedic surgery
following removal of bone tumors. Despite the advances in bone regeneration, the use of …
following removal of bone tumors. Despite the advances in bone regeneration, the use of …
Impaired In Vitro Erythropoiesis following Deletion of the Scl (Tal1) +40 Enhancer Is Largely Compensated for In Vivo despite a Significant Reduction in Expression
R Ferreira, D Spensberger, Y Silber… - … and cellular biology, 2013 - Taylor & Francis
The Scl (Tal1) gene encodes a helix-loop-helix transcription factor essential for
hematopoietic stem cell and erythroid development. The Scl+ 40 enhancer is situated …
hematopoietic stem cell and erythroid development. The Scl+ 40 enhancer is situated …
Dissecting the inflammatory response in melanoma
L Barker - 2016 - ora.ox.ac.uk
While the immune system can control tumour growth, regulatory mechanisms, necessary in
preventing immunopathology & autoimmunity, contribute to tumour progression impeding …
preventing immunopathology & autoimmunity, contribute to tumour progression impeding …
Investigating the origin of primitive erythrocytes and vascular smooth muscle cells
MM Stefanska - 2013 - search.proquest.com
The haemangioblast is defined as a embryonic mesodermal progenitor cell with
haematopoietic, endothelial and vascular smooth muscle potential. During ES cell …
haematopoietic, endothelial and vascular smooth muscle potential. During ES cell …
[PDF][PDF] Single site-specific integration targeting coupled with embryonic stem cell differentiation
AC Wilkinson, DK Goode, YH Cheng - Biology open, 2 (11), 2013 - academia.edu
Comprehensive analysis of cis-regulatory elements is key to understanding the dynamic
gene regulatory networks that control embryonic development. While transgenic animals …
gene regulatory networks that control embryonic development. While transgenic animals …