Cells rely on surveillance systems such as autophagy to handle protein alterations and
organelle damage. Dysfunctional autophagy, an evolutionarily conserved cellular …

Over 20 years ago, the synaptic protein α-synuclein was identified as the primary component
of the Lewy bodies (LBs) that are a sine qua non of Parkinson's disease (PD). Since that …

Parkinson's disease (PD) is characterized by a profound loss of dopaminergic neurons in
the substantia nigra, accompanied by chronic neuroinflammation, mitochondrial dysfunction …

In Parkinson's disease, synucleinopathy is hypothesized to spread from the enteric nervous
system, via the vagus nerve, to the CNS. Here, we compare, in baboon monkeys, the …

Recessive variants in GBA1 cause Gaucher disease, a prevalent form of lysosome storage
disease. GBA1 encodes a lysosomal enzyme that hydrolyzes glucosylceramide (GlcCer) …

Parkinson's disease (PD) is a progressive neurodegenerative disease where dopaminergic
neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and …

Mutations in the GBA1 gene are the most common genetic risk factor for Parkinson's disease
(PD) and dementia with Lewy bodies (DLB). GBA1 encodes the lysosomal lipid hydrolase …

Dysfunction of the endolysosomal system is implicated in the pathogenesis of both sporadic
and familial Parkinson disease (PD). Variants in genes encoding lysosomal proteins have …

GBA encodes the lysosomal enzyme glucocerebrosidase (GCase), an enzyme involved in
sphingolipid metabolism. Mutations in the GBA gene are numerically the most important risk …

Parkinson's disease (PD) is a common neurodegenerative disorder that primarily affects the
elderly. While the etiology of PD is likely multifactorial with the involvement of genetic …