Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

Stress can influence health throughout the lifespan, yet there is little agreement about what
types and aspects of stress matter most for human health and disease. This is in part …

Biological aging of human organ systems reflects the interplay of age, chronic disease,
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …

Leukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the
measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We …

Importance Telomeres protect DNA from damage. Because they shorten with each mitotic
cycle, leukocyte telomere length (LTL) serves as a mitotic clock. Reduced LTL has been …

INTRODUCTION Telomeres are DNA-protein complexes located at the end of chromosomes
that protect chromosome ends from degradation and fusion. The DNA component of …

Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …

The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …

Telomere biology was first studied in maize, ciliates, yeast, and mice, and in recent decades,
it has informed understanding of common disease mechanisms with broad implications for …