Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

Learning to recognize and respond to potential threats is crucial for survival. Pavlovian
threat conditioning represents a key paradigm for investigating the neurobiological …

Preclinical and clinical studies implicate endocannabinoids (eCBs) in fear extinction, but the
underlying neural circuit basis of these actions is unclear. Here, we employed in vivo …

Central nervous system neurons communicate via fast synaptic transmission mediated by
ligand-gated ion channel (LGIC) receptors and slower neuromodulation mediated by G …

Cannabis has been used for hundreds of years, with its ability to dampen feelings of anxiety
often reported as a primary reason for use. Only recently has the specific role cannabinoids …

Psychiatric disorders associated with psychological trauma, stress and anxiety are a highly
prevalent and increasing cause of morbidity worldwide. Current therapeutic approaches …

This narrative review article summarizes the current state of knowledge regarding the
relationship between the endocannabinoid system (ECS) and aggression across multiple …

The endocannabinoid system (ECS) regulates brain development and function, energy
metabolism and stress in a sex-, age-and tissue-dependent manner. The ECS comprises …

The activity of specific populations of neurons in different brain areas makes decisions
regarding proper synaptic transmission, the ability to make adaptations in response to …

Post-Traumatic Stress Disorder (PTSD) is a complex disorder involving dysregulation of
stress-related hormones and neurotransmitter systems. Research focused on the …