Cancer is one of the leading causes of death, and despite increased research in recent
years, control of advanced-stage disease and optimal therapeutic responses remain elusive …

Cancer research has traditionally focused on the characterization of individual molecular
mechanisms that can contribute to cancer. Due to the multiple levels of genomic and non …

Background Chromosome instability leads to aneuploidy, a state in which cells have
abnormal numbers of chromosomes, and is found in two out of three cancers. In a …

Abstract The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9
nuclease system has allowed the generation of disease models and the development of …

Micronuclei research has regained its popularity due to the realization that genome chaos, a
rapid and massive genome re-organization under stress, represents a major common …

Genome chaos, a process of complex, rapid genome re-organization, results in the
formation of chaotic genomes, which is followed by the potential to establish stable …

When discussing chromosomal instability, most of the literature focuses on the
characterization of individual molecular mechanisms. These studies search for genomic and …

The basis for the gene mutation theory of cancer that dominates current molecular cancer
research consists of: the belief that gene‐level aberrations such as mutations are the main …

Cancer is traditionally labeled a “cellular growth problem.” However, it is fundamentally an
issue of macroevolution where new systems emerge from tissue by breaking various …

While the importance of chromosomal/nuclear variations vs. gene mutations in diseases is
becoming more appreciated, less is known about its genomic basis. Traditionally …