Evolution of 3D chromatin organization at different scales
RD Acemel, DG Lupiáñez - Current opinion in genetics & development, 2023 - Elsevier
Highlights•Chromatin folding into topologically associated domains (TADs) is pervasive
across animal groups.•TADs are plastic entities composed of genomic strata from different …
across animal groups.•TADs are plastic entities composed of genomic strata from different …
Predicting genome architecture: challenges and solutions
P Belokopytova, V Fishman - Frontiers in genetics, 2021 - frontiersin.org
Genome architecture plays a pivotal role in gene regulation. The use of high-throughput
methods for chromatin profiling and 3-D interaction mapping provide rich experimental data …
methods for chromatin profiling and 3-D interaction mapping provide rich experimental data …
The 3D architecture of the pepper genome and its relationship to function and evolution
The organization of chromatin into self-interacting domains is universal among eukaryotic
genomes, though how and why they form varies considerably. Here we report a …
genomes, though how and why they form varies considerably. Here we report a …
Variable number tandem repeats mediate the expression of proximal genes
M Bakhtiari, J Park, YC Ding, S Shleizer-Burko… - Nature …, 2021 - nature.com
Variable number tandem repeats (VNTRs) account for significant genetic variation in many
organisms. In humans, VNTRs have been implicated in both Mendelian and complex …
organisms. In humans, VNTRs have been implicated in both Mendelian and complex …
Characterization of structural variation in Tibetans reveals new evidence of high-altitude adaptation and introgression
C Quan, Y Li, X Liu, Y Wang, J Ping, Y Lu, G Zhou - Genome Biology, 2021 - Springer
Background Structural variation (SV) acts as an essential mutational force shaping the
evolution and function of the human genome. However, few studies have examined the role …
evolution and function of the human genome. However, few studies have examined the role …
3DSNP 2.0: update and expansion of the noncoding genomic variant annotation database
The rapid development of single-molecule long-read sequencing (LRS) and single-cell
assay for transposase accessible chromatin sequencing (scATAC-seq) technologies …
assay for transposase accessible chromatin sequencing (scATAC-seq) technologies …
Topologically associating domains and their role in the evolution of genome structure and function in Drosophila
Topologically associating domains (TADs) were recently identified as fundamental units of
three-dimensional eukaryotic genomic organization, although our knowledge of the …
three-dimensional eukaryotic genomic organization, although our knowledge of the …
Expanding the conservation genomics toolbox: incorporating structural variants to enhance genomic studies for species of conservation concern
Structural variants (SVs) are large rearrangements (> 50 bp) within the genome that impact
gene function and the content and structure of chromosomes. As a result, SVs are a …
gene function and the content and structure of chromosomes. As a result, SVs are a …
[HTML][HTML] Exploring 3D chromatin contacts in gene regulation: the evolution of approaches for the identification of functional enhancer-promoter interaction
Mechanisms underlying gene regulation are key to understand how multicellular organisms
with various cell types develop from the same genetic blueprint. Dynamic interactions …
with various cell types develop from the same genetic blueprint. Dynamic interactions …
Applications of advanced technologies for detecting genomic structural variation
Chromosomal structural variation (SV) encompasses a heterogenous class of genetic
variants that exerts strong influences on human health and disease. Despite their …
variants that exerts strong influences on human health and disease. Despite their …