Naturally occurring modified ribonucleosides
PJ McCown, A Ruszkowska, CN Kunkler… - Wiley …, 2020 - Wiley Online Library
The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …
Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics
R Shi, S Ying, Y Li, L Zhu, X Wang, H Jin - Cell Death & Disease, 2021 - nature.com
Abstract N6-methyladenosine (m6A), the most prevalent and reversible modification of
mRNA in mammalian cells, has recently been extensively studied in epigenetic regulation …
mRNA in mammalian cells, has recently been extensively studied in epigenetic regulation …
[HTML][HTML] Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/PTEN/Akt signaling cascade through DGCR8
X Zha, X Xi, X Fan, M Ma, Y Zhang, Y Yang - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Abstract Methyltransferase-like protein 3 (METTL3) regulates multiple cell functions and
diseases by modulating N 6-methyladenosine (m 6 A) modifications. However, it is still …
diseases by modulating N 6-methyladenosine (m 6 A) modifications. However, it is still …
A single-cell atlas of Plasmodium falciparum transmission through the mosquito
Malaria parasites have a complex life cycle featuring diverse developmental strategies, each
uniquely adapted to navigate specific host environments. Here we use single-cell …
uniquely adapted to navigate specific host environments. Here we use single-cell …
Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum
Plasmodium falciparum secretes extracellular vesicles (Pf EVs) that contain parasite-derived
RNA. However, the significance of the secreted RNA remains unexplored. Here, we …
RNA. However, the significance of the secreted RNA remains unexplored. Here, we …
Ghost authors revealed: The structure and function of human N6‐methyladenosine RNA methyltransferases
K Breger, CN Kunkler, NJ O'Leary… - Wiley …, 2024 - Wiley Online Library
Despite the discovery of modified nucleic acids nearly 75 years ago, their biological
functions are still being elucidated. N 6‐methyladenosine (m6A) is the most abundant …
functions are still being elucidated. N 6‐methyladenosine (m6A) is the most abundant …
Emerging biology of noncoding RNAs in malaria parasites
In eukaryotic organisms, noncoding RNAs (ncRNAs) have been implicated as important
regulators of multifaceted biological processes, including transcriptional, posttranscriptional …
regulators of multifaceted biological processes, including transcriptional, posttranscriptional …
5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes
5-methylcytosine (m5C) is an important epitranscriptomic modification involved in
messenger RNA (mRNA) stability and translation efficiency in various biological processes …
messenger RNA (mRNA) stability and translation efficiency in various biological processes …
Malaria parasite stress tolerance is regulated by DNMT2-mediated tRNA cytosine methylation
Malaria parasites need to cope with changing environmental conditions that require strong
countermeasures to ensure pathogen survival in the human and mosquito hosts. The …
countermeasures to ensure pathogen survival in the human and mosquito hosts. The …
[HTML][HTML] Comparative spatial proteomics of Plasmodium-infected erythrocytes
Plasmodium parasites contribute to one of the highest global infectious disease burdens. To
achieve this success, the parasite has evolved a range of specialized subcellular …
achieve this success, the parasite has evolved a range of specialized subcellular …