The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by …

Circadian rhythms play an influential role in nearly all aspects of physiology and behavior in
the vast majority of species on Earth. The biological clockwork that regulates these rhythms …

Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …

Circadian rhythms optimize physiology and health by temporally coordinating cellular
function, tissue function, and behavior. These endogenous rhythms dampen with age and …

Circadian disruption aggravates age-related decline and mortality. However, it remains
unclear whether circadian enhancement can retard aging in mammals. We previously …

Light exerts a wide range of effects on mammalian physiology and behavior. As well as
synchronizing circadian rhythms to the external environment, light has been shown to …

Circadian (daily) rhythms are present in almost all plants and animals. In mammals, a brain
clock located in the hypothalamic suprachiasmatic nucleus maintains synchrony between …

Levels of numerous hormones vary across the day and night. Such fluctuations are not only
attributable to changes in sleep/wakefulness and other behaviors but also to a circadian …