Circadian rhythm as a therapeutic target
The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …
changes and internal physiology. The clock endows the host with temporal precision and …
Molecular mechanisms and physiological importance of circadian rhythms
A Patke, MW Young, S Axelrod - Nature reviews Molecular cell biology, 2020 - nature.com
To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
Importance of circadian timing for aging and longevity
VA Acosta-Rodríguez, F Rijo-Ferreira, CB Green… - Nature …, 2021 - nature.com
Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by …
can be achieved by controlling how much and/or when food is provided, as well as by …
The aging clock: circadian rhythms and later life
Circadian rhythms play an influential role in nearly all aspects of physiology and behavior in
the vast majority of species on Earth. The biological clockwork that regulates these rhythms …
the vast majority of species on Earth. The biological clockwork that regulates these rhythms …
Epigenetic regulation of ageing: linking environmental inputs to genomic stability
Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …
Circadian rhythms, time-restricted feeding, and healthy aging
ENC Manoogian, S Panda - Ageing research reviews, 2017 - Elsevier
Circadian rhythms optimize physiology and health by temporally coordinating cellular
function, tissue function, and behavior. These endogenous rhythms dampen with age and …
function, tissue function, and behavior. These endogenous rhythms dampen with age and …
Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge
Circadian disruption aggravates age-related decline and mortality. However, it remains
unclear whether circadian enhancement can retard aging in mammals. We previously …
unclear whether circadian enhancement can retard aging in mammals. We previously …
Light and cognition: roles for circadian rhythms, sleep, and arousal
Light exerts a wide range of effects on mammalian physiology and behavior. As well as
synchronizing circadian rhythms to the external environment, light has been shown to …
synchronizing circadian rhythms to the external environment, light has been shown to …
Disruption of circadian clocks has ramifications for metabolism, brain, and behavior
Circadian (daily) rhythms are present in almost all plants and animals. In mammals, a brain
clock located in the hypothalamic suprachiasmatic nucleus maintains synchrony between …
clock located in the hypothalamic suprachiasmatic nucleus maintains synchrony between …
Circadian system, sleep and endocrinology
CJ Morris, D Aeschbach, FAJL Scheer - Molecular and cellular …, 2012 - Elsevier
Levels of numerous hormones vary across the day and night. Such fluctuations are not only
attributable to changes in sleep/wakefulness and other behaviors but also to a circadian …
attributable to changes in sleep/wakefulness and other behaviors but also to a circadian …