Complex chromosome rearrangements, known as chromoanagenesis, are widespread in
cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of …

The members of the Poly (ADP‐ribose) polymerase (PARP) superfamily are involved in
several biological processes and, in particular, in the DNA damage response (DDR). The …

Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic
rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer …

Chromothripsis is a recently identified mutational phenomenon, by which a presumably
single catastrophic event generates extensive genomic rearrangements of one or a few …

Chromothripsis is a frequent form of genome instability, whereby a presumably single
catastrophic event generates extensive genomic rearrangements of one or multiple …

Improved identification of structural variants (SVs) in cancer can lead to more targeted and
effective treatment options as well as advance our basic understanding of the disease and …

TP53 is a key tumor suppressor gene with protean functions associated with preservation of
genomic balance, including regulation of cellular senescence, apoptotic pathways …

Chromothripsis is a catastrophic event of chromosomal instability that involves intensive
fragmentation and rearrangements within localized chromosomal regions. However, its …

Abstract Chromothripsis is detectable in 20–30% of newly diagnosed multiple myeloma
(NDMM) patients and is emerging as a new independent adverse prognostic factor. In this …

Karyotype complexity has major prognostic value in many malignancies. There is no
consensus on the definition of a complex karyotype, and the prognostic impact of karyotype …