Disparities in acute myeloid leukemia treatments and outcomes

AK Eisfeld - Current Opinion in Hematology, 2024 - journals.lww.com
An increasing number of studies have not only shown persistent survival disparities between
Black and non-Hispanic White AML patients, but uncovered a multitude of contributors that …

High early death rates, treatment resistance, and short survival of Black adolescents and young adults with AML

KT Larkin, D Nicolet, BJ Kelly, K Mrózek… - Blood …, 2022 - ashpublications.org
Survival of patients with acute myeloid leukemia (AML) is inversely associated with age, but
the impact of race on outcomes of adolescent and young adult (AYA; range, 18-39 years) …

From Descriptive to Functional Genomics of Leukemias Focusing on Genome Engineering Techniques

B Balla, F Tripon, C Banescu - International Journal of Molecular Sciences, 2021 - mdpi.com
Genome engineering makes the precise manipulation of DNA sequences possible in a cell.
Therefore, it is essential for understanding gene function. Meganucleases were the start of …

Association of social deprivation with survival in younger adult patients with AML: an Alliance study

M Rebechi, J Kohlschmidt, K Mrózek, D Nicolet… - Blood …, 2023 - ashpublications.org
Cancer health disparities are differences in health outcomes observed across population
groups, including patients with acute myeloid leukemia (AML), characterized by various …

The clinical implications of BCOR mutations in a large cohort of acute myeloid leukemia patients: a 5-year single-center retrospective study

D Hu, K Shen, YS Guo, X Bao, N Dong… - Leukemia & …, 2024 - Taylor & Francis
To elucidate the effect of BCOR mutation (BCOR mut) on clinical outcomes, we included a
total of 899 consecutive AML patients in a single-center during July 2016 to December 2021 …

Jumping translocation involving chromosome 13q in a patient with Crohn's Disease and inv (16)(p13. 1q22)/CBFB-MYH11 acute myeloid leukemia

S Clarke, R de Kraa, H Chuah, K Creeper, MF Leahy… - Cancer Genetics, 2022 - Elsevier
Jumping translocations (JT) are rare chromosomal rearrangements caused by the
translocation of one donor chromosome segment to two or more recipient chromosomes. In …

Case Report: Successful therapy with all-trans retinoic acid combined with chemotherapy followed by hematopoietic stem cell transplantation for acute promyelocytic leukemia …

L Chen, H Zhu, Y Zhu, W Jin, F Dong, J Li, J Hu… - Frontiers in …, 2022 - frontiersin.org
Acute promyelocytic leukemia (APL) is characterized by the balanced translocation of
chromosomes 15 and 17, resulting in the formation of PML-RARA fusion gene. More than …

OPEN ACCESS EDITED BY

JL Spivak, GA Croci, SS Chuang… - Case Reports in …, 2023 - books.google.com
Langerhans cell histiocytosis (LCH) and acute myeloid leukemia (AML) are distinct entities
of blood neoplasms, and the exact developmental origin of both neoplasms is considered to …

Clinical exome sequencing reveals an important role for clinical diagnosis of intellectual disability with definition of seven novel variants.

S Yalcintepe, I Gorker, L Bozatli, HS Guler… - Neurology …, 2023 - search.ebscohost.com
Intellectual disability can be defined as a significantly below-average general mental
function, accompanied by environmental adaptation and behavioural deterioration. Patient …

Crenolanib for treating flt3 mutated proliferative disorders associated mutations

VK Jain - US Patent App. 17/667,781, 2022 - Google Patents
The present invention includes methods for treating a human patient with Crenolanib,
wherein the human patient is suffering from a FLT3 mutated leukemia, the method …