The glycosylation in SARS-CoV-2 and its receptor ACE2

Y Gong, S Qin, L Dai, Z Tian - Signal Transduction and Targeted …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …

Fundamentals, applications, and future directions of bioelectrocatalysis

H Chen, O Simoska, K Lim, M Grattieri, M Yuan… - Chemical …, 2020 - ACS Publications
Bioelectrocatalysis is an interdisciplinary research field combining biocatalysis and
electrocatalysis via the utilization of materials derived from biological systems as catalysts to …

D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1

R Zhang, Y Yang, W Dong, M Lin… - Proceedings of the …, 2022 - National Acad Sciences
Breast cancer is the most frequent malignancy in women worldwide, and triple-negative
breast cancer (TNBC) patients have the worst prognosis and highest risk of recurrence. The …

TIM3 comes of age as an inhibitory receptor

Y Wolf, AC Anderson, VK Kuchroo - Nature Reviews Immunology, 2020 - nature.com
T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM
family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and …

Tau post-translational modifications: dynamic transformers of tau function, degradation, and aggregation

C Alquezar, S Arya, AW Kao - Frontiers in neurology, 2021 - frontiersin.org
Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

Synergistic insights into human health from aptamer-and antibody-based proteomic profiling

M Pietzner, E Wheeler, J Carrasco-Zanini… - Nature …, 2021 - nature.com
Affinity-based proteomics has enabled scalable quantification of thousands of protein targets
in blood enhancing biomarker discovery, understanding of disease mechanisms, and …

Metformin promotes antitumor immunity via endoplasmic-reticulum-associated degradation of PD-L1

JH Cha, WH Yang, W Xia, Y Wei, LC Chan, SO Lim… - Molecular cell, 2018 - cell.com
Metformin has been reported to possess antitumor activity and maintain high cytotoxic T
lymphocyte (CTL) immune surveillance. However, the functions and detailed mechanisms of …

General features to enhance enzymatic activity of poly (ethylene terephthalate) hydrolysis

CC Chen, X Han, X Li, P Jiang, D Niu, L Ma, W Liu… - Nature Catalysis, 2021 - nature.com
Abstract Poly (ethylene terephthalate)(PET) is the most abundant polyester plastic and a
major contributor to plastic pollution. Is PETase, from the PET-assimilating bacterium …

Protein glycosylation and tumor microenvironment alterations driving cancer hallmarks

A Peixoto, M Relvas-Santos, R Azevedo… - Frontiers in …, 2019 - frontiersin.org
Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …

[HTML][HTML] N-linked protein glycosylation in the ER

M Aebi - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2013 - Elsevier
N-linked protein glycosylation in the endoplasmic reticulum (ER) is a conserved two phase
process in eukaryotic cells. It involves the assembly of an oligosaccharide on a lipid carrier …