Abstract Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1. 14) is the first and rate-limiting
enzyme in the classic bile acid synthesis pathway. Much progress has been made in …

Bile acids are increasingly being appreciated as complex metabolic integrators and
signalling factors and not just as lipid solubilizers and simple regulators of bile-acid …

Background Bile acids are important endocrine modulators of intestinal and hepatic
signalling cascades orchestrating critical pathophysiological processes in various liver …

Activation of farnesoid X receptor (FXR) markedly attenuates development of atherosclerosis
in animal models. However, the underlying mechanism is not well elucidated. Here, we …

Long non-coding RNAs (lncRNAs) are important biological mediators that regulate
numerous cellular processes. New experimental evidence suggests that lncRNAs play …

Objective Our objective was to investigate the role of bile acids in hepatic steatosis reduction
after vertical sleeve gastrectomy (VSG). Design and Methods High fat diet (HFD)‐induced …

Maintenance of bile acid (BA) homeostasis is essential to achieve their physiologic functions
and avoid their toxic effects. The marked differences in BA composition between preclinical …

Moderate consumption of red wine reduces risk of death from cardiovascular disease. The
polyphenols in red wine are ultimately responsible for this effect, exerting antiatherogenic …

The bile acid (BA) submetabolome can partially reflect either physiological or pathological
status of vertebrates. The structural diversity, however, extensively hinders BA …

Bile acids (BAs) are amphipathic molecules produced from cholesterol by the liver. Expelled
from the gallbladder upon meal ingestion, BAs serve as fat solubilizers in the intestine. BAs …