[HTML][HTML] Trends in insulin resistance: insights into mechanisms and therapeutic strategy

M Li, X Chi, Y Wang, S Setrerrahmane… - Signal transduction and …, 2022 - nature.com
The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Epigenetic inheritance of polycystic ovary syndrome—challenges and opportunities for treatment

E Stener-Victorin, Q Deng - Nature Reviews Endocrinology, 2021 - nature.com
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and is
associated with a substantially increased lifetime risk of comorbidities, including type 2 …

Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): an update

S Abraham Gnanadass, Y Divakar Prabhu… - Archives of Gynecology …, 2021 - Springer
Background Polycystic ovarian syndrome (PCOS) is the most prevalent metabolic disorder
in reproductive-age women. It is indeed a multifactorial condition evidenced by ovarian …

Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome

DA Dumesic, SE Oberfield, E Stener-Victorin… - Endocrine …, 2015 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a heterogeneous and complex disorder that has both
adverse reproductive and metabolic implications for affected women. However, there is …

Roles of oxidative stress in polycystic ovary syndrome and cancers

T Zuo, M Zhu, W Xu - Oxidative medicine and cellular longevity, 2016 - Wiley Online Library
Oxidative stress (OS) has received extensive attention in the last two decades, because of
the discovery that abnormal oxidation status was related to patients with chronic diseases …

Extra-and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence

J Qiao, HL Feng - Human reproduction update, 2011 - academic.oup.com
BACKGROUND Polycystic ovary syndrome (PCOS) is a common metabolic dysfunction and
heterogeneous endocrine disorder in women of reproductive age. Although patients with …

[HTML][HTML] Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study

S Furat Rencber, S Kurnaz Ozbek, C Eraldemır… - Journal of ovarian …, 2018 - Springer
Background PCOS is a reproductive hormonal abnormality and a metabolic disorder. It is
frequently associated with insulin resistance, hyperandrogenism, chronic inflammation, and …

Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome

ASL Caldwell, MC Edwards, R Desai… - Proceedings of the …, 2017 - National Acad Sciences
Polycystic ovary syndrome (PCOS) is a complex hormonal disorder characterized by
reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS remain …

[HTML][HTML] Hyperandrogenism in polycystic ovarian syndrome and role of CYP gene variants: a review

S Ashraf, M Nabi, F Rashid, S Amin - Egyptian Journal of Medical …, 2019 - Springer
Background Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder
characterized by anovulation, hyperandrogenism, and polycystic ovarian morphology. The …