Role of the extracellular signal-regulated kinase 1/2 signaling pathway in ischemia-reperfusion injury

T Kong, M Liu, B Ji, B Bai, B Cheng, C Wang - Frontiers in physiology, 2019 - frontiersin.org
Extracellular signal-regulated kinase 1/2 (ERK1/2), an important member of the mitogen-
activated protein kinase family, is found in many organisms, and it participates in …

Mechanisms of testicular torsion and potential protective agents

E Karaguzel, M Kadihasanoglu, O Kutlu - Nature Reviews Urology, 2014 - nature.com
Testicular torsion is a urological emergency most commonly seen in adolescence, involving
a decrease in blood flow in the testis resulting from torsion of the spermatic cord that can …

Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis

H Zhang, SM Moochhala, M Bhatia - The Journal of Immunology, 2008 - journals.aai.org
Hydrogen sulfide (H 2 S) up-regulates inflammatory response in several inflammatory
diseases. However, to date, little is known about the molecular mechanism by which H 2 S …

Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-κB signaling

SF Ang, SM Moochhala, PA MacAry, M Bhatia - PloS one, 2011 - journals.plos.org
Hydrogen sulfide (H2S) has been shown to induce transient receptor potential vanilloid 1
(TRPV1)-mediated neurogenic inflammation in polymicrobial sepsis. However, endogenous …

Late hormonal function after testicular torsion

C Romeo, P Impellizzeri, T Arrigo, P Antonuccio… - Journal of Pediatric …, 2010 - Elsevier
INTRODUCTION: Testicular torsion may be an important cause of male infertility. We aimed
to investigate the late hormonal function in patients with testicular ischemia/reperfusion …

[HTML][HTML] Medical perspective in testicular ischemia‑reperfusion injury

S Arena, R Iacona, P Antonuccio… - Experimental and …, 2017 - spandidos-publications.com
Testicular torsion or torsion of the spermatic cord is one of the most serious urological
conditions. It causes testicular injury, which potentially leads to male subfertility. The turning …

Retracted: Research Article Flavocoxid Protects Against Cadmium-Induced Disruption of the Blood-Testis Barrier and Improves Testicular Damage and Germ Cell …

L Minutoli, A Micali, A Pisani, D Puzzolo… - Toxicological …, 2015 - academic.oup.com
Cadmium (Cd) causes male infertility. There is the need to identify safe treatments
counteracting this toxicity. Flavocoxid is a flavonoid that induces a balanced inhibition of …

Polydeoxyribonucleotide, an Adenosine-A2A Receptor Agonist, Preserves Blood Testis Barrier from Cadmium-Induced Injury

F Squadrito, A Micali, M Rinaldi, N Irrera… - Frontiers in …, 2017 - frontiersin.org
Cadmium (Cd) impairs blood-testis barrier (BTB). Polydeoxyribonucleotide (PDRN), an
adenosine A2A agonist, has positive effects on male reproductive system. We investigated …

Testicular torsion in vivo models: Mechanisms and treatments

A Minas, S Mahmoudabadi, NS Gamchi… - …, 2023 - Wiley Online Library
Background Testicular torsion is a condition in which a testis rotates around its longitudinal
axis and twists the spermatic cord. This in turn results in a significant decrease in blood flow …

Substance p upregulates cyclooxygenase-2 and prostaglandin E metabolite by activating ERK1/2 and NF-κB in a mouse model of burn-induced remote Acute lung …

SWS Sio, SF Ang, J Lu, S Moochhala… - The Journal of …, 2010 - journals.aai.org
Acute lung injury (ALI) is a major cause of mortality in burn patients, even without direct
inhalational injury. Identification of early mediators that instigate ALI after burn and of the …