Fluorogenic probes for disease-relevant enzymes
Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …
Base excision repair
HE Krokan, M Bjørås - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
Base excision repair (BER) corrects DNA damage from oxidation, deamination and
alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is …
alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is …
[HTML][HTML] DNA methylation, its mediators and genome integrity
H Meng, Y Cao, J Qin, X Song, Q Zhang… - … journal of biological …, 2015 - ncbi.nlm.nih.gov
DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …
Advances in quantum dot-based biosensors for DNA-modifying enzymes assay
Q Zhang, X Zhang, F Ma, C Zhang - Coordination Chemistry Reviews, 2022 - Elsevier
DNA-modifying enzymes participate in various genetic functions (eg, DNA replication,
repairing, and recombination) through alternating certain DNA sequence, and the …
repairing, and recombination) through alternating certain DNA sequence, and the …
Terminal deoxynucleotidyl transferase combined CRISPR-Cas12a amplification strategy for ultrasensitive detection of uracil-DNA glycosylase with zero background
YC Du, SY Wang, YX Wang, JY Ma, DX Wang… - Biosensors and …, 2021 - Elsevier
A simple and highly sensitive biosensing strategy was reported by cascading terminal
deoxynucleotidyl transferase (TdT)-catalyzed substrate extension and CRISPR-Cas12a …
deoxynucleotidyl transferase (TdT)-catalyzed substrate extension and CRISPR-Cas12a …
DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae
S Boiteux, S Jinks-Robertson - Genetics, 2013 - academic.oup.com
DNA repair mechanisms are critical for maintaining the integrity of genomic DNA, and their
loss is associated with cancer predisposition syndromes. Studies in Saccharomyces …
loss is associated with cancer predisposition syndromes. Studies in Saccharomyces …
The hyper IgM syndromes: Epidemiology, pathogenesis, clinical manifestations, diagnosis and management
Abstract Hyper Immunoglobulin M syndrome (HIGM) is a rare primary immunodeficiency
disorder characterized by low or absent levels of serum IgG, IgA, IgE and normal or …
disorder characterized by low or absent levels of serum IgG, IgA, IgE and normal or …
The hyper IgM syndromes
N Qamar, RL Fuleihan - Clinical reviews in allergy & immunology, 2014 - Springer
The hyper IgM syndromes are a group of rare inherited immune deficiency disorders
characterized by impairment of immunoglobulin isotype switching resulting from defects in …
characterized by impairment of immunoglobulin isotype switching resulting from defects in …
[HTML][HTML] Regulatory mechanisms of one-carbon metabolism enzymes
One-carbon metabolism is a central metabolic pathway critical for the biosynthesis of several
amino acids, methyl group donors, and nucleotides. The pathway mostly relies on the …
amino acids, methyl group donors, and nucleotides. The pathway mostly relies on the …
Excision repair-initiated enzyme-assisted bicyclic cascade signal amplification for ultrasensitive detection of uracil-DNA glycosylase
L Wang, M Ren, Q Zhang, B Tang, C Zhang - Analytical chemistry, 2017 - ACS Publications
Uracil-DNA glycosylase (UDG) is an important base excision repair (BER) enzyme
responsible for the repair of uracil-induced DNA lesion and the maintenance of genomic …
responsible for the repair of uracil-induced DNA lesion and the maintenance of genomic …