Postsynaptic nAChRs in the peripheral nervous system are critical for neuromuscular and
autonomic neurotransmission. Pre-and peri-synaptic nAChRs in the brain modulate …

We discuss models for the activation and desensitization of α7 nicotinic acetylcholine
receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators …

Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent
agonists, allosteric activating PAMs and neutral or silent allosteric modulators are …

The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that
modulates neuronal excitability, largely by allowing Ca2+ permeation. Agonist binding …

Considerable progress has been made in recent years towards the identification and
characterisation of novel subtype-selective modulators of nicotinic acetylcholine receptors …

We conducted electrophysiological and molecular docking studies using a heterologous
expression system (Xenopus oocytes) to compare the effects of four neonicotinoids …

Human behavior can be controlled by physical or psychological dependencies associated
with addiction. One of the most insidious addictions in our society is the use of tobacco …

The α7 nicotinic acetylcholine receptor (nAChR) silent agonists, able to induce receptor
desensitization and promote the α7 metabotropic function, are emerging as new promising …

A lack of selectivity of classical agonists for the nicotinic acetylcholine receptors (nAChR)
has prompted us to identify and develop a distinct scaffold of α7 nAChR-selective ligands …

It has been almost 20 years since the discovery and crystallization of a structural surrogate,
the Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP), comprising the …