The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
JL Hsu, MC Hung - Cancer and Metastasis Reviews, 2016 - Springer
Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
Targeting the EGFR signaling pathway in cancer therapy
P Seshacharyulu, MP Ponnusamy… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …
recently been made, wherein EGFR and its family members have emerged as useful …
Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy
To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier
into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance …
into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance …
Understanding resistance to EGFR inhibitors—impact on future treatment strategies
DL Wheeler, EF Dunn, PM Harari - Nature reviews Clinical oncology, 2010 - nature.com
EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis.
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Expression and function of the epidermal growth factor receptor in physiology and disease
J Chen, F Zeng, SJ Forrester, S Eguchi… - Physiological …, 2016 - journals.physiology.org
The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …
Protein localization in disease and therapy
The eukaryotic cell is organized into membrane-covered compartments that are
characterized by specific sets of proteins and biochemically distinct cellular processes. The …
characterized by specific sets of proteins and biochemically distinct cellular processes. The …
EGFR signaling enhances aerobic glycolysis in triple-negative breast cancer cells to promote tumor growth and immune escape
Oncogenic signaling reprograms cancer cell metabolism to augment the production of
glycolytic metabolites in favor of tumor growth. The ability of cancer cells to evade …
glycolytic metabolites in favor of tumor growth. The ability of cancer cells to evade …
Nuclear EGFR as a molecular target in cancer
TM Brand, M Iida, N Luthar, MM Starr… - Radiotherapy and …, 2013 - Elsevier
The epidermal growth factor receptor (EGFR) has been one of the most targeted receptors in
the field of oncology. While anti-EGFR inhibitors have demonstrated clinical success in …
the field of oncology. While anti-EGFR inhibitors have demonstrated clinical success in …
EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment
Epidermal growth factor receptor (EGFR) overexpression is associated with resistance to
chemotherapy and radiotherapy. It modulates DNA repair after radiation-induced damage …
chemotherapy and radiotherapy. It modulates DNA repair after radiation-induced damage …
Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab
TM Brand, M Iida, DL Wheeler - Cancer biology & therapy, 2011 - Taylor & Francis
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase belonging to the
HER family of receptor tyrosine kinases. Receptor activation upon ligand binding leads to …
HER family of receptor tyrosine kinases. Receptor activation upon ligand binding leads to …