The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …

To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic
pathways of the majority of tRNA modifications include a methylation step (s). Recent studies …

Background In recent years there has been an increasing problem with Staphylococcus
aureus strains that are resistant to treatment with existing antibiotics. An important starting …

Streptomycin has been an important drug for the treatment of tuberculosis since its discovery
in 1944. But numerous strains of Mycobacterium tuberculosis, the bacterial pathogen that …

Pseudomonas aeruginosa produces abundant levels of rhamnolipid biosurfactants which
exhibit remarkable chemical and physical characteristics, making these compounds …

Members of the large superclass of P-loop GTPases share a core domain with a conserved
three-dimensional structure. In eukaryotes, these proteins are implicated in various crucial …

This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …

Modifying RNA enzymes are highly specific for substrate—rRNA or tRNA—and the target
position. In Escherichia coli, there are very few multisite acting enzymes, and only one …

Transfer RNA (tRNA) molecules are sumptuously decorated with evolutionary conserved
post-transcriptional nucleoside modifications that are essential for structural stability and …

Flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are utilized as
coenzymes in many biochemical reduction-oxidation reactions owing to the ability of the …