Type 2 diabetes mellitus (T2DM) is a very complex and multifactorial metabolic disease
characterized by insulin resistance and β cell failure leading to elevated blood glucose …

Diets are currently characterized by elevated sugar intake, mainly due to the increased
consumption of processed sweetened foods and drinks during the last 40 years. Diet is the …

Phenolic compounds from marine organisms are far less studied than those from terrestrial
sources since their structural diversity and variability require powerful analytical tools …

Protein function and flexibility is directly related to the native distribution of its structural
elements and any alteration in protein architecture leads to several abnormalities and …

Age-related, non-communicable chronic inflammatory diseases represent the major 21st
century health problem. Especially in Western countries, the prevalence of non …

Advanced glycation endproducts (AGEs), pathophysiological important posttranslational
modifications, are formed in vivo by a non-enzymatic reaction of proteins with reactive …

Metabolic syndrome (MetS), ie a cluster of physiological and biochemical abnormalities can
lead to diabetic nephropathy (DN). Insulin resistance, impaired fasting glucose are the main …

The presence and biological significance of circulating glycated insulin has been evaluated
by high-pressure liquid chromatography (HPLC), electrospray ionization mass spectrometry …

Background Chrysophyllum cainito L., a tropical fruit tree, has been used as an alternative
medicine for the treatment of diabetic patients in many countries. However, there is very …

Nonenzymatic glycation of proteins, peptides and other macromolecules (the Maillard
reaction) has been implicated in a number of pathologies, most clearly in diabetes mellitus …