Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years
Twenty‐five years ago, a new physiological preparation called the working heart–brainstem
preparation (WHBP) was introduced with the claim it would provide a new platform allowing …
preparation (WHBP) was introduced with the claim it would provide a new platform allowing …
Women at altitude: Sex-related physiological responses to exercise in hypoxia
A Raberin, J Burtscher, T Citherlet, G Manferdelli… - Sports Medicine, 2024 - Springer
Sex differences in physiological responses to various stressors, including exercise, have
been well documented. However, the specific impact of these differences on exposure to …
been well documented. However, the specific impact of these differences on exposure to …
P2X3 receptor antagonism attenuates the progression of heart failure
Despite advances in the treatment of heart failure, prognosis is poor, mortality high and there
remains no cure. Heart failure is associated with reduced cardiac pump function, autonomic …
remains no cure. Heart failure is associated with reduced cardiac pump function, autonomic …
Excessive respiratory modulation of blood pressure triggers hypertension
C Menuet, S Le, B Dempsey, AA Connelly, JL Kamar… - Cell metabolism, 2017 - cell.com
The etiology of hypertension, the world's biggest killer, remains poorly understood, with
treatments targeting the established symptom, not the cause. The development of …
treatments targeting the established symptom, not the cause. The development of …
Interaction between the retrotrapezoid nucleus and the parafacial respiratory group to regulate active expiration and sympathetic activity in rats
The retrotrapezoid nucleus (RTN) contains chemosensitive cells that distribute CO2-
dependent excitatory drive to the respiratory network. This drive facilitates the function of the …
dependent excitatory drive to the respiratory network. This drive facilitates the function of the …
Hypoxia sensing in the body: An update on the peripheral and central mechanisms
DB Zoccal, BN Vieira, LR Mendes… - Experimental …, 2024 - Wiley Online Library
An adequate supply of O2 is essential for the maintenance of cellular activity. Systemic or
local hypoxia can be experienced during decreased O2 availability or associated with …
local hypoxia can be experienced during decreased O2 availability or associated with …
Inhibitory control of active expiration by the Bötzinger complex in rats
KC Flor, WH Barnett, M Karlen‐Amarante… - The Journal of …, 2020 - Wiley Online Library
Key points Contraction of abdominal muscles at the end of expiration during metabolic
challenges (such as hypercapnia and hypoxia) improves pulmonary ventilation. The …
challenges (such as hypercapnia and hypoxia) improves pulmonary ventilation. The …
Non‐chemosensitive parafacial neurons simultaneously regulate active expiration and airway patency under hypercapnia in rats
AA de Britto, DJA Moraes - The Journal of Physiology, 2017 - Wiley Online Library
Key points Hypercapnia or parafacial respiratory group (pFRG) disinhibition at normocapnia
evokes active expiration in rats by recruitment of pFRG late‐expiratory (late‐E) neurons. We …
evokes active expiration in rats by recruitment of pFRG late‐expiratory (late‐E) neurons. We …
Commonalities and differences in carotid body dysfunction in hypertension and heart failure
ISA Felippe, RD Río, H Schultz… - The Journal of …, 2023 - Wiley Online Library
Carotid body pathophysiology is associated with many cardiovascular–respiratory–
metabolic diseases. This pathophysiology reflects both hyper‐sensitivity and hyper‐tonicity …
metabolic diseases. This pathophysiology reflects both hyper‐sensitivity and hyper‐tonicity …
The Kölliker-Fuse nucleus orchestrates the timing of expiratory abdominal nerve bursting
WH Barnett, SEM Jenkin, WK Milsom… - Journal of …, 2018 - journals.physiology.org
Coordination of respiratory pump and valve muscle activity is essential for normal breathing.
A hallmark respiratory response to hypercapnia and hypoxia is the emergence of active …
A hallmark respiratory response to hypercapnia and hypoxia is the emergence of active …