PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development
HH Lau, NAJ Krentz, F Abaitua… - Nature …, 2023 - nature.com
The coding variant (p. Arg192His) in the transcription factor PAX4 is associated with an
altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for …
altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for …
PAX4 loss of function alters human endocrine cell development and influences diabetes risk
HH Lau, NAJ Krentz, F Abaitua, M Perez-Alcantara… - bioRxiv, 2022 - biorxiv.org
Diabetes is a major chronic disease with an excessive healthcare burden on society. A
coding variant (p. Arg192His) in the transcription factor PAX4 is uniquely and reproducibly …
coding variant (p. Arg192His) in the transcription factor PAX4 is uniquely and reproducibly …