Pharmacological approach for neuroprotection after cardiac arrest—a narrative review of current therapies and future neuroprotective cocktail

RC Choudhary, M Shoaib, S Sohnen… - Frontiers in …, 2021 - frontiersin.org
Cardiac arrest (CA) results in global ischemia-reperfusion injury damaging tissues in the
whole body. The landscape of therapeutic interventions in resuscitation medicine has …

Forensic NMR metabolomics: one more arrow in the quiver

E Locci, G Bazzano, A Chighine, F Locco, E Ferraro… - Metabolomics, 2020 - Springer
Introduction NMR metabolomics is increasingly used in forensics, due to the possibility of
investigating both endogenous metabolic profiles and exogenous molecules that may help …

Metabolic alterations associated with polycystic ovary syndrome: A UPLC Q-Exactive based metabolomic study

X Chen, T Lu, X Wang, X Sun, J Zhang, K Zhou, X Ji… - Clinica chimica acta, 2020 - Elsevier
Background The polycystic ovary syndrome (PCOS) is the most common endocrine and
metabolic disorder syndrome of women in reproductive age. Metabolomic studies of the …

Exploring perinatal asphyxia by metabolomics

E Locci, G Bazzano, R Demontis, A Chighine, V Fanos… - Metabolites, 2020 - mdpi.com
Brain damage related to perinatal asphyxia is the second cause of neuro-disability
worldwide. Its incidence was estimated in 2010 as 8.5 cases per 1000 live births worldwide …

Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations

M Shoaib, RC Choudhary, J Choi, N Kim… - Scientific reports, 2020 - nature.com
Cardiac arrest (CA) is a leading cause of death and there is a necessity for animal models
that accurately represent human injury severity. We evaluated a rat model of severe CA …

Tissue‐specific metabolic profiles after prolonged cardiac arrest reveal brain metabolome dysfunction predominantly after resuscitation

J Choi, M Shoaib, T Yin, G Nayyar… - Journal of the …, 2019 - Am Heart Assoc
Background Cardiac arrest (CA) has been a leading cause of death for many decades.
Despite years of research, we still do not understand how each organ responds to the …

Metabolomics improves the histopathological diagnosis of asphyxial deaths: an animal proof-of-concept model

E Locci, A Chighine, A Noto, G Ferino, A Baldi… - Scientific reports, 2021 - nature.com
The diagnosis of mechanical asphyxia remains one of the most difficult issues in forensic
pathology. Asphyxia ultimately results in cardiac arrest (CA) and, as there are no specific …

Microbial translocation and perinatal asphyxia/hypoxia: a systematic review

DI Matara, A Pouliakis, T Xanthos, R Sokou, G Kafalidis… - Diagnostics, 2022 - mdpi.com
The microbiome is vital for the proper function of the gastrointestinal tract (GIT) and the
maintenance of overall wellbeing. Gut ischemia may lead to disruption of the intestinal …

Personalized physiology-guided resuscitation in highly monitored patients with cardiac arrest—the PERSEUS resuscitation protocol

A Chalkias, E Arnaoutoglou, T Xanthos - Heart failure reviews, 2019 - Springer
Resuscitation guidelines remain uniform across all cardiac arrest patients, focusing on the
delivery of chest compressions to a standardized rate and depth and algorithmic …

Infant urinary metabolomic profile in a fatal acute methadone intoxication

A Chighine, M Porcu, G Ferino, N Lenigno… - International Journal of …, 2022 - Springer
A case report suspicious for a Sudden Infant Death Syndrome is here described.
Pathological findings were consistent with an acute respiratory failure while toxicological …